Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Trade Name
Synonyms PVS-RIPO|NSC-719277|NSC719277
Drug Descriptions

PVSRIPO is an oncolytic virus comprising a recombinant poliovirus/rhinovirus chimera, which targets CD155 (Necl5)-expressing tumor cells, and potentially induces enhanced anti-tumor immune response and tumor cell cytotoxicity (PMID: 21984883, PMID: 24939611).

CAS Registry Number NA
NCIT ID C99459


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + PVSRIPO Atezolizumab PVSRIPO 0 1
Lomustine + PVSRIPO Lomustine PVSRIPO 0 1
Nivolumab + PVSRIPO Nivolumab PVSRIPO 0 1
Pembrolizumab + PVSRIPO PVSRIPO Pembrolizumab 0 1
PVSRIPO + unspecified PD-1 antibody PVSRIPO unspecified PD-1 antibody 0 2

Additional content available in CKB BOOST