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Trade Name
Synonyms PVS-RIPO|NSC-719277|NSC719277
Drug Descriptions

PVSRIPO is an oncolytic virus comprising a recombinant poliovirus/rhinovirus chimera, which targets CD155 (Necl5)-expressing tumor cells, and potentially induces enhanced anti-tumor immune response and tumor cell cytotoxicity (PMID: 21984883, PMID: 24939611).

CAS Registry Number NA
NCIT ID C99459


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + PVSRIPO Atezolizumab PVSRIPO 0 1
Lomustine + PVSRIPO Lomustine PVSRIPO 0 1
Nivolumab + PVSRIPO Nivolumab PVSRIPO 0 1
Pembrolizumab + PVSRIPO PVSRIPO Pembrolizumab 0 1
PVSRIPO + unspecified PD-1 antibody PVSRIPO unspecified PD-1 antibody 0 2

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