Therapy Detail
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| Therapy Name | Atezolizumab + Carboplatin + Etoposide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Atezolizumab | Tecentriq | RG7446|MPDL3280A | Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 | Tecentriq (atezolizumab) is a monoclonal antibody against PD-L1 (CD274), preventing activation of its receptor, potentially enhancing T-cell-mediated immune response to neoplasms and inhibiting T-cell inactivation (PMID: 29449897). Tecentriq (atezolizumab) is FDA approved for use in PD-L1 positive (IC >/= 5%) advanced or metastatic urothelial carcinoma not eligible for cisplatin-containing chemotherapy, in advanced or metastatic urothelial carcinoma not eligible for chemotherapy, in metastatic non-small cell lung cancer (NSCLC) progressed on platinum-containing therapy, as first-line therapy in metastatic NSCLC with high PD-L1 expression (TC>/=50% or IC>/=10%) and without EGFR or ALK alterations, for adjuvant treatment in patients with PD-L1-positive (>=1% tumor cell expression) NSCLC, in combination with bevacizumab, paclitaxel, and carboplatin as first-line therapy for non-squamous NSCLC with no EGFR or ALK aberrations, in combination with paclitaxel protein-bound and carboplatin in metastatic non-squamous NSCLC with no EGFR or ALK aberrations, in combination with carboplatin and etoposide in extensive-stage small cell lung cancer, in combination with bevacizumab in hepatocellular carcinoma without prior systemic therapy, in combination with Cotellic (cobimetinib) and Zelboraf (vemurafenib) in unresectable or metastatic BRAF V600-mutated melanoma, and in pediatric and adult patients with unresectable or metastatic alveolar soft part sarcoma (FDA.gov). |
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| Etoposide | Vepesid | EPEG|Eposin|VP-16|VP-16-213 | TOPO2 inhibitor 5 | Vepesid (etoposide) binds to and inhibits DNA topoisomerase II, resulting in accumulated DNA damage, inhibition of replication, and cell death (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04256421 | Phase III | Atezolizumab + Carboplatin + Etoposide + Tiragolumab Atezolizumab + Carboplatin + Etoposide | A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer (SKYSCRAPER-02) | Active, not recruiting | USA | NZL | NLD | ITA | GBR | ESP | DEU | BEL | AUT | AUS | 13 |
| NCT05091567 | Phase III | Atezolizumab + Carboplatin + Etoposide Atezolizumab + Carboplatin + Etoposide + Lurbinectedin | A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer (IMforte) | Active, not recruiting | USA | ITA | GBR | ESP | DEU | BEL | 7 |
| NCT03811002 | Phase II | Atezolizumab + Carboplatin + Etoposide Atezolizumab + Cisplatin + Etoposide Cisplatin + Etoposide Carboplatin + Etoposide | Chemoradiation With or Without Atezolizumab in Treating Patients With Limited Stage Small Cell Lung Cancer | Active, not recruiting | USA | 1 |
| NCT04610684 | Phase II | Atezolizumab Atezolizumab + Carboplatin + Etoposide | Chemotherapy and Atezolizumab for Patients With Extensive Stage Small Cell Lung Cancer (SCLC) With Untreated, Asymptomatic Brain Metastases | Terminated | USA | 0 |
| NCT05468489 | Phase III | Atezolizumab + Carboplatin + Etoposide Carboplatin + Etoposide + Serplulimab | To Evaluate Efficacy and Safety of HLX10 + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC | Recruiting | USA | 0 |
| NCT04923776 | Phase II | Atezolizumab + Carboplatin + Etoposide | Liver Directed RT + Chemo-immunotherapy for ES-SCLC | Recruiting | USA | 0 |
| NCT02763579 | Phase III | Atezolizumab + Carboplatin + Etoposide Carboplatin + Etoposide | A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage Small Cell Lung Cancer (IMpower133) | Completed | USA | ITA | GBR | FRA | ESP | DEU | AUT | AUS | 13 |
| NCT05312671 | Phase II | Atezolizumab + Carboplatin + Etoposide Atezolizumab + Cisplatin + Etoposide | Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer | Recruiting | USA | 0 |
| NCT03041311 | Phase II | Atezolizumab + Carboplatin + Etoposide + Trilaciclib Atezolizumab + Carboplatin + Etoposide | Carboplatin, Etoposide, and Atezolizumab With or Without Trilaciclib (G1T28), a CDK 4/6 Inhibitor, in Extensive Stage Small Cell Lung Cancer (SCLC) | Terminated | USA | FRA | ESP | 4 |
| NCT06110572 | Phase Ib/II | Atezolizumab + Carboplatin + Etoposide | Phase I/II Trial in ES-SCLC to Enhance Response to Atezolizumab Plus Chemotherapy With Total Body Irradiation (TESSERACT) | Recruiting | USA | 0 |
| NCT02748889 | Phase Ib/II | Carboplatin + Etoposide Atezolizumab + Carboplatin + Etoposide | Carboplatin Plus Etoposide With or Without MPDL3280A in Untreated Extensive Stage Small Cell Lung Cancer | Terminated | USA | 0 |
| NCT04487756 | Phase Ib/II | Atezolizumab + Carboplatin + Etoposide | Combination of Atezolizumab With Dendritic Cell Vaccine in Patients With Lung Cancer (VENEZO-LUNG) | Active, not recruiting | ESP | 0 |
| NCT05224141 | Phase III | Carboplatin + Etoposide + MK-7684A Cisplatin + Etoposide + MK-7684A Atezolizumab + Cisplatin + Etoposide Atezolizumab + Carboplatin + Etoposide | Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008, KEYVIBE-008) | Active, not recruiting | USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | AUT | AUS | 15 |
| NCT05058651 | Phase II | Atezolizumab + Carboplatin + Etoposide Atezolizumab + Cisplatin + Etoposide Cisplatin + Etoposide Carboplatin + Etoposide | Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Metastatic Small Cell Neuroendocrine Carcinomas That Originate Outside the Lung | Recruiting | USA | 0 |
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