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Drug Name PEGPH20
Trade Name
Synonyms Pegvorhyaluronidase alfa
Drug Descriptions

Pegvorhyaluronidase alfa (PEGPH20) is a pegylated version of hyaluronidase, which degrades endogenous hyaluronic acid within tumors, potentially resulting in decreased growth of tumor cells and increased penetration of other therapeutic agents (PMID: 32706635).

CAS Registry Number 1620390-06-8
NCIT ID C82659


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Cisplatin + Gemcitabine + PEGPH20 Atezolizumab Cisplatin Gemcitabine PEGPH20 0 1
Atezolizumab + PEGPH20 Atezolizumab PEGPH20 0 3
Cetuximab + PEGPH20 Cetuximab PEGPH20 0 1
Cisplatin + Gemcitabine + PEGPH20 Cisplatin Gemcitabine PEGPH20 0 1
Gemcitabine + Nab-paclitaxel + PEGPH20 Gemcitabine Nab-paclitaxel PEGPH20 0 1
PEGPH20 + Pembrolizumab PEGPH20 Pembrolizumab 0 3

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