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|Therapy Name||Ad-E6E7 + Atezolizumab + MG1-E6E7|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ad-E6E7||Ad-E6E7 is an adenovirus-based cancer vaccine that expresses versions of human papilloma virus (HPV) E6 and E7 genes altered to remove regions required for oncogenic transformation, which may result in increased immune response against HPV-positive tumors (PMID: 22918471).|
|Atezolizumab||Tecentriq||RG7446|MPDL3280A||Immune Checkpoint Inhibitor 95 PD-L1/PD-1 antibody 58||Tecentriq (atezolizumab) is a monoclonal antibody against PD-L1 (CD274), preventing activation of its receptor, potentially enhancing T-cell-mediated immune response to neoplasms and inhibiting T-cell inactivation (PMID: 29449897). Tecentriq (atezolizumab) is FDA approved for use in patients with advanced urothelial carcinoma, metastatic non-small cell lung cancer (NSCLC) progressed on platinum-containing therapy, in combination with bevacizumab, paclitaxel, and carboplatin for non-squamous NSCLC with no EGFR or ALK aberrations, in combination with paclitaxel protein-bound for advanced or metastatic triple-negative breast cancer expressing PD-L1, and in combination with carboplatin and etoposide for small cell lung cancer (FDA.gov).|
|MG1-E6E7||MGI-E6E7 is oncolytic Maraba virus engineered to express attenuated E6 and E7 from human papilloma virus (HPV), which may increase immune response against HPV-positive tumors (PMID: 29544689).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03618953||Phase I||Ad-E6E7 + Atezolizumab + MG1-E6E7||This is a Trial of MG1-E6E7 With Ad-E6E7 and Atezolizumab in Patients With HPV Associated Cancers (Kingfisher)||Active, not recruiting|