Therapy Detail

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Therapy Name Ad-E6E7 + Atezolizumab + MG1-E6E7
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ad-E6E7 Ad-E6E7 is an adenovirus-based cancer vaccine that expresses versions of human papilloma virus (HPV) E6 and E7 genes altered to remove regions required for oncogenic transformation, which may result in increased immune response against HPV-positive tumors (PMID: 22918471, PMID: 26851223).
Atezolizumab Tecentriq RG7446|MPDL3280A Immune Checkpoint Inhibitor 155 PD-L1/PD-1 antibody 105 Tecentriq (atezolizumab) is a monoclonal antibody against PD-L1 (CD274), preventing activation of its receptor, potentially enhancing T-cell-mediated immune response to neoplasms and inhibiting T-cell inactivation (PMID: 29449897). Tecentriq (atezolizumab) is FDA approved for use in PD-L1 positive (IC >/= 5%) advanced or metastatic urothelial carcinoma not eligible for cisplatin-containing chemotherapy, in advanced or metastatic urothelial carcinoma not eligible for chemotherapy, in metastatic non-small cell lung cancer (NSCLC) progressed on platinum-containing therapy, as first-line therapy in metastatic NSCLC with high PD-L1 expression (TC>/=50% or IC>/=10%) and without EGFR or ALK alterations, for adjuvant treatment in patients with PD-L1-positive (>=1% tumor cell expression) NSCLC, in combination with bevacizumab, paclitaxel, and carboplatin as first-line therapy for non-squamous NSCLC with no EGFR or ALK aberrations, in combination with paclitaxel protein-bound and carboplatin in metastatic non-squamous NSCLC with no EGFR or ALK aberrations, in combination with carboplatin and etoposide in extensive-stage small cell lung cancer, in combination with bevacizumab in hepatocellular carcinoma without prior systemic therapy, in combination with Cotellic (cobimetinib) and Zelboraf (vemurafenib) in unresectable or metastatic BRAF V600-mutated melanoma, and in pediatric and adult patients with unresectable or metastatic alveolar soft part sarcoma (FDA.gov).
MG1-E6E7 MGI-E6E7 is oncolytic Maraba virus engineered to express attenuated E6 and E7 from human papilloma virus (HPV), which may increase immune response against HPV-positive tumors (PMID: 29544689).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03618953 Phase I Ad-E6E7 + Atezolizumab + MG1-E6E7 This is a Trial of MG1-E6E7 With Ad-E6E7 and Atezolizumab in Patients With HPV Associated Cancers (Kingfisher) Terminated USA | CAN 0


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