Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Navoximod
Trade Name
Synonyms NLG919|RG6078|GDC-0919|RO7077339-001
Drug Descriptions

Navoximod (GDC-0919) inhibits indoleamine 2,3-dioxygenase 1 (IDO1), which decreases production of kynurenine from tryptophan, potentially resulting in reduced T-cell suppression and increased antitumor immune response (PMID: 31124055, PMID: 29247038).

DrugClasses IDO1 Inhibitor 12
CAS Registry Number 1402837-78-8
NCIT ID C113793

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Navoximod Atezolizumab Navoximod 0 0
Navoximod Navoximod 0 2
Navoximod + NLG802 NLG802 Navoximod 0 1


Additional content available in CKB BOOST