Drug Detail


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Drug Name Navoximod
Trade Name
Synonyms NLG919|RG6078|GDC-0919|RO7077339-001
Drug Descriptions

Navoximod (GDC-0919) inhibits indoleamine 2,3-dioxygenase 1 (IDO1), which decreases production of kynurenine from tryptophan, potentially resulting in reduced T-cell suppression and increased antitumor immune response (PMID: 31124055, PMID: 29247038).

DrugClasses IDO1 Inhibitor 12
CAS Registry Number 1402837-78-8
NCIT ID C113793


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Navoximod Atezolizumab Navoximod 0 0
Navoximod Navoximod 0 2
Navoximod + NLG802 NLG802 Navoximod 0 1

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