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|Therapy Name||DS-3201b + Irinotecan|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|DS-3201b||DS-3201|Valemetostat Tosylate||EZH1 inhibitor 4 EZH2 inhibitor 19||DS-3201b inhibits EZH1 and EZH2, resulting in decreased H3K27 trimethylation and potentially leading to decreased tumor growth (Blood 2017 130:2073, PMID: 30658046).|
|Irinotecan||Camptosar||CPT-11|Onivyde||TOPO1 inhibitor 10||Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03879798||Phase Ib/II||DS-3201b + Irinotecan||DS-3201b and Irinotecan for Patients With Recurrent Small Cell Lung Cancer||Completed||USA||0|