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|Therapy Name||MLN0905 + Rituximab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MLN0905||MLN-0905|MLN 0905||PLK1 Inhibitor 16||MLN0905 is a small molecule inhibitor of PLK1, which may result in cell cycle arrest and antitumor activity (PMID: 22609854, PMID: 28184925).|
|Rituximab||Rituxan||IDEC-C2B8|MabThera||CD20 Antibody 10||Rituxan (rituximab) is a chimeric mononclonal antibody that binds to CD20 on B-cells, resulting in induction of complement-dependent and antibody-dependent cytotoxicity, and potentially leading to decreased B-cell tumor growth (PMID: 28983798). Rituxan (rituximab) is FDA approved for use as monotherapy or in combination with chemotherapy in CD20-positive B-cell non-Hodgkin lymphoma, and in combination with fludarabine and cyclophosphamide in CD20-positive chronic lymphocytic leukemia (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||diffuse large B-cell lymphoma||not applicable||MLN0905 + Rituximab||Preclinical||Actionable||In a preclinical study, MLN0905 combined with MabThera (rituximab) resulted in a synergistic effect when treating a diffuse large B-cell lymphoma xenograft model, demonstrating a decrease in tumor volume and increased survival (PMID: 22609854).||22609854|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|