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Drug Name Zanubrutinib
Trade Name Brukinsa
Synonyms BGB-3111
Drug Descriptions

Brukinsa (zanubrutinib) inhibits Bruton tyrosine kinase (BTK), leading to decreased B-cell activation and reduced growth of BTK over-expressing cells (PMID: 31378456). Brukinsa (zanubrutinib) is FDA approved for use in patients with mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) (FDA.gov).

DrugClasses BTK inhibitor 36
CAS Registry Number 1691249-45-2
NCIT ID C141428

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Obinutuzumab + Venetoclax + Zanubrutinib Bendamustine Obinutuzumab Venetoclax Zanubrutinib 0 1
BGB-10188 + Zanubrutinib BGB-10188 Zanubrutinib 0 1
BGB-11417 + Zanubrutinib BGB-11417 Zanubrutinib 0 2
Cyclophosphamide + Doxorubicin + Rituximab + Vincristine Sulfate + Zanubrutinib Cyclophosphamide Doxorubicin Rituximab Vincristine Sulfate Zanubrutinib 0 1
Cyclophosphamide + Fludarabine + Lisocabtagene maraleucel + Zanubrutinib Cyclophosphamide Fludarabine Lisocabtagene maraleucel Zanubrutinib 0 1
Lenalidomide + Tafasitamab-cxix + Zanubrutinib Lenalidomide Tafasitamab-cxix Zanubrutinib 0 1
Obinutuzumab + Venetoclax + Zanubrutinib Obinutuzumab Venetoclax Zanubrutinib 0 3
Obinutuzumab + Zanubrutinib Obinutuzumab Zanubrutinib 0 3
Pemetrexed Disodium + Zanubrutinib Pemetrexed Disodium Zanubrutinib 0 1
Rituximab + Zanubrutinib Rituximab Zanubrutinib 0 7
Tafasitamab-cxix + Zanubrutinib Tafasitamab-cxix Zanubrutinib 0 2
Venetoclax + Zanubrutinib Venetoclax Zanubrutinib 0 3
Zanubrutinib Zanubrutinib 3 11


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