Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Zanubrutinib
Trade Name Brukinsa
Synonyms BGB-3111
Drug Descriptions

Brukinsa (zanubrutinib) inhibits Bruton tyrosine kinase (BTK), leading to decreased B-cell activation and reduced growth of BTK over-expressing cells (PMID: 31378456). Brukinsa (zanubrutinib) is FDA approved for use in patients with mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) (FDA.gov).

DrugClasses BTK inhibitor 35
CAS Registry Number 1691249-45-2
NCIT ID C141428

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Obinutuzumab + Venetoclax + Zanubrutinib Bendamustine Obinutuzumab Venetoclax Zanubrutinib 0 1
BGB-10188 + Zanubrutinib BGB-10188 Zanubrutinib 0 1
BGB-11417 + Zanubrutinib BGB-11417 Zanubrutinib 0 2
Cyclophosphamide + Doxorubicin + Rituximab + Vincristine Sulfate + Zanubrutinib Cyclophosphamide Doxorubicin Rituximab Vincristine Sulfate Zanubrutinib 0 1
Cyclophosphamide + Fludarabine + Lisocabtagene maraleucel + Zanubrutinib Cyclophosphamide Fludarabine Lisocabtagene maraleucel Zanubrutinib 0 1
Lenalidomide + Tafasitamab-cxix + Zanubrutinib Lenalidomide Tafasitamab-cxix Zanubrutinib 0 1
Obinutuzumab + Venetoclax + Zanubrutinib Obinutuzumab Venetoclax Zanubrutinib 0 3
Obinutuzumab + Zanubrutinib Obinutuzumab Zanubrutinib 0 3
Pemetrexed Disodium + Zanubrutinib Pemetrexed Disodium Zanubrutinib 0 1
Rituximab + Zanubrutinib Rituximab Zanubrutinib 0 5
Tafasitamab-cxix + Zanubrutinib Tafasitamab-cxix Zanubrutinib 0 2
Venetoclax + Zanubrutinib Venetoclax Zanubrutinib 0 3
Zanubrutinib Zanubrutinib 3 11


Additional content available in CKB BOOST