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|Therapy Name||Chlorambucil + Rituximab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Rituximab||Rituxan||IDEC-C2B8|MabThera||CD20 Antibody 11||Rituxan (rituximab) is a chimeric mononclonal antibody that binds to CD20 on B-cells, resulting in induction of complement-dependent and antibody-dependent cytotoxicity, and potentially leading to decreased B-cell tumor growth (PMID: 28983798). Rituxan (rituximab) is FDA approved for use as monotherapy or in combination with chemotherapy in CD20-positive B-cell non-Hodgkin lymphoma, and in combination with fludarabine and cyclophosphamide in CD20-positive chronic lymphocytic leukemia (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||MALT lymphoma||not applicable||Chlorambucil + Rituximab||Phase III||Actionable||In a Phase III trial, Chlorambucil and Rituxan (Rituximab) combination treatment resulted in improved event-free survival (HR=0.54) but not longer overall survival in patients with mucosa-associated lymphoid tissue lymphoma (PMID: 28355112).||28355112|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|