Drug Detail


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Drug Name VLS-101
Trade Name
Synonyms VLS 101|VLS101|Zilovertamab Vedotin|MK 2140|MK2140|MK-2140
Drug Descriptions

VLS-101 is an antibody-drug conjugate (ADC) comprising a ROR1-targeted antibody linked to monomethyl auristatin E (MMAE), which delivers the drug to ROR1-expressing tumor cells, potentially resulting in increased apoptosis and decreased tumor growth (Blood (2019) 134 (Supplement_1): 2856).

DrugClasses ROR1 Antibody 4
CAS Registry Number NA
NCIT ID C157772


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Rituximab + VLS-101 Bendamustine Rituximab VLS-101 0 1
Gemcitabine + Oxaliplatin + Rituximab + VLS-101 Gemcitabine Oxaliplatin Rituximab VLS-101 0 1
VLS-101 VLS-101 0 3

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