Therapy Detail
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| Therapy Name | VLS-101 |
| Synonyms | |
| Therapy Description |
VLS-101 is an antibody-drug conjugate (ADC) comprising a ROR1-targeted antibody linked to monomethyl auristatin E (MMAE), which delivers the drug to ROR1-expressing tumor cells, potentially resulting in increased apoptosis and decreased tumor growth (Blood (2019) 134 (Supplement_1): 2856). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| VLS-101 | VLS 101|VLS101|Zilovertamab Vedotin|MK 2140|MK2140|MK-2140 | ROR1 Antibody 5 | VLS-101 is an antibody-drug conjugate (ADC) comprising a ROR1-targeted antibody linked to monomethyl auristatin E (MMAE), which delivers the drug to ROR1-expressing tumor cells, potentially resulting in increased apoptosis and decreased tumor growth (Blood (2019) 134 (Supplement_1): 2856). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03833180 | Phase I | VLS-101 | A Phase 1 Dose-Escalation and Cohort-Expansion of VLS-101 in Hematologic Malignancies | Completed | USA | 0 |
| NCT05458297 | Phase II | VLS-101 ARQ 531 + VLS-101 | A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination With Nemtabrutinib (MK-1026) in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006) | Recruiting | USA | ITA | GBR | ESP | DEU | CAN | 14 |
| NCT04504916 | Phase II | VLS-101 | A Study of VLS-101 in Patients With Solid Tumors | Completed | USA | CAN | 0 |
| NCT05144841 | Phase II | VLS-101 | A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004) | Active, not recruiting | USA | ITA | FRA | ESP | CAN | 12 |
| NCT05562830 | Phase Ib/II | VLS-101 | A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A) | Active, not recruiting | USA | ESP | AUS | 4 |
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