Drug Detail


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Drug Name Enzastaurin
Trade Name
Synonyms LY317615|LY-317615
Drug Descriptions

Enzastaurin (LY317615) is a selective inhibitor PKC-beta, with activity against other PKC isoforms at higher concentrations, which decreases downstream signaling and potentially results in reduced tumor growth (PMID: 16103100, PMID: 17671157, PMID: 22253748, PMID: 32250167).

DrugClasses PKC beta Inhibitor 6
CAS Registry Number 170364-57-5
NCIT ID C77392


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ARV-771 + Enzastaurin ARV-771 Enzastaurin 0 0
Cyclophosphamide + Doxorubicin + Enzastaurin + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Enzastaurin Prednisone Rituximab Vincristine Sulfate 0 0
Enzalutamide + Enzastaurin Enzalutamide Enzastaurin 0 0
Enzastaurin Enzastaurin 0 2
Enzastaurin + Temozolomide Enzastaurin Temozolomide 0 1
Enzastaurin + YK-4-279 Enzastaurin YK-4-279 0 0

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