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|Therapy Name||Avelumab + rhIL-15|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Avelumab||Bavencio||MSB0010718C||Immune Checkpoint Inhibitor 94 PD-L1/PD-1 antibody 65||Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov).|
|rhIL-15||recombinant human interleukin-15|rhIL15||rHIL-15 is the recombinant human interleukin-15 which may stimulate and enhance anti-tumor immune response (PMID: 18582400, PMID: 31266741).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT04150562||Phase II||Avelumab + rhIL-15||Avelumab (Bavencio) With IL-15 in Subjects With Clear-Cell Renal Carcinoma||Recruiting|
|NCT03905135||Phase I||Avelumab + rhIL-15||Interleukin-15 (IL-5) in Combination With Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies||Recruiting|