Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Therapy Name||Avelumab + FT516|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Avelumab||Bavencio||MSB0010718C||Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 89||Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov).|
|FT516||FT-516|iPSC-derived CD16-expressing Natural Killer Cells FT516||FT516 are iPSC-derived allogeneic NK cells engineered to express hnCD16, which may stimulate anti-tumor immune response (Cancer Res 2019;79(13 Suppl):Abstract nr 3191).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04551885||Phase I||Cyclophosphamide + Fludarabine Avelumab + FT516 Aldesleukin||FT516 in Combination With Monoclonal Antibodies in Advanced Solid Tumors||Active, not recruiting||USA||0|