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|Therapy Name||Avelumab + VSV-hIFNbeta-NIS|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Avelumab||Bavencio||MSB0010718C||Immune Checkpoint Inhibitor 148 PD-L1/PD-1 antibody 93||Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov).|
|VSV-hIFNbeta-NIS||Voyager-V1|VV1||VSV-hIFNbeta-NIS is oncolytic vesticular stomatitis virus engineered to express human interferon-beta (hIFN-beta) and sodium iodide symporter (NIS), which may inhibit tumor growth (PMID: 26712908, PMID: 22425894).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT02923466||Phase Ib/II||Avelumab + VSV-hIFNbeta-NIS VSV-hIFNbeta-NIS||Trial of Intratumoral Administration of Recombinant Vesicular Stomatitis Virus Monotherapy and in Combination With Avelumab in Patients With Refractory Solid Tumors||Completed||USA||0|