Therapy Detail

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Therapy Name Enzalutamide + ZEN-3694
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Enzalutamide Xtandi MDV3100|ASP9785 Hormone - Anti-androgens 27 Xtandi (enzalutamide) is a second-generation small molecule androgen receptor (AR) inhibitor that inhibits AR signaling, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA approved for use in patients with castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer (FDA.gov).
ZEN-3694 ZEN003694|BETi ZEN-3694|ZEN3694|ZEN 3694 BET Inhibitor (Pan) 27 ZEN-3694 is a pan BET inhibitor that suppresses AR signaling, which potentially inhibits tumor progression (Cancer Res 2016;76(14 Suppl):Abstract nr LB-207, PMID: 32694156).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable Enzalutamide + ZEN-3694 Preclinical - Cell culture Actionable In a preclinical study, ZEN-3694 in combination with Xtandi (enzalutamide) synergistically inhibited proliferation of an AR-positive prostate cancer cell line in culture (Cancer Res 2016;76(14 Suppl):Abstract nr LB-207). detail...
Unknown unknown prostate cancer not applicable Enzalutamide + ZEN-3694 Phase Ib/II Actionable In a Phase Ib/II trial, combination of ZEN-3694 and Xtandi (enzalutamide) demonstrated safety in metastatic castration-resistant prostate cancer patients resistant to prior androgen signaling inhibitors, and resulted in a median radiographic progression-free survival (rPFS) of 9.0 months and a composite median radiographic or clinical PFS of 5.5 months, patients with lower baseline AR activity demonstrated prolonged median rPFS (10.4 v 4.3 months) compared to patients with high AR activity (PMID: 32694156). 32694156

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02711956 Phase I Enzalutamide + ZEN-3694 A Study of ZEN003694 in Combination With Enzalutamide in Patients With Metastatic Castration-Resistant Prostate Cancer Active, not recruiting
NCT04145375 Phase Ib/II Enzalutamide + ZEN-3694 Continuation Protocol for ZEN003694 in Patients Experiencing Clinical Benefit While Enrolled in a ZEN003694 Protocol Enrolling by invitation


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