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|Therapy Name||H3B-5942 + Ribociclib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|H3B-5942||CS-0047696||Hormone - Anti-estrogens 22||H3B-5942 is a selective estrogen receptor covalent antagonist, which antagonizes wild-type and mutant forms of estrogen receptor alpha, potentially resulting in decreased tumor cell proliferation and reduced tumor growth (PMID: 29991605).|
|Ribociclib||Kisqali||LEE011||CDK4/6 Inhibitor 11||Kisqali (ribociclib) is a dual CDK4/6 inhibitor, which may induce cell cycle arrest and reduce proliferation in cancer cells (PMID: 24045179). Kisqali (ribociclib) is FDA-approved in combination with an aromatase inhibitor in women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer, and in combination with Faslodex (fulvestrant) in postmenopausal women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|