Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name TW-37
Trade Name
Synonyms
Drug Descriptions

TW-37 is a third-generation BH3 mimetic that inhibits BCL2, MCL1, and with lesser affinity, BCL-XL, which may result in increased tumor cell apoptosis and increased sensitivity to chemotherapeutics (PMID: 17404107, PMID: 32257914).

DrugClasses BCL-XL inhibitor 14 BCL2 inhibitor 27 MCL1 Inhibitor 18
CAS Registry Number 877877-35-5
NCIT ID NA

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Trametinib + TW-37 TW-37 Trametinib 2 0
TW-37 TW-37 0 0
TW-37 + Vemurafenib TW-37 Vemurafenib 2 0


Additional content available in CKB BOOST