Drug Detail


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Drug Name TW-37
Trade Name
Drug Descriptions

TW-37 is a third-generation BH3 mimetic that inhibits BCL2, MCL1, and with lesser affinity, BCL-XL, which may result in increased tumor cell apoptosis and increased sensitivity to chemotherapeutics (PMID: 17404107, PMID: 32257914).

DrugClasses BCL-XL inhibitor 14 BCL2 inhibitor 27 MCL1 Inhibitor 18
CAS Registry Number 877877-35-5


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Trametinib + TW-37 TW-37 Trametinib 2 0
TW-37 TW-37 0 0
TW-37 + Vemurafenib TW-37 Vemurafenib 2 0

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