Drug Detail


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Drug Name CFT1946
Trade Name
Synonyms CFT-1946|CFT 1946
Drug Descriptions

CFT1946 is a bifunctional degradation activation compound (BiDAC) degrader composed of a ligand that targets the BRAF kinase domain linked to a Cereblon ligand, which potentially induces degradation of mutant BRAF and inhibition of tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2158).

DrugClasses BRAF Inhibitor 25
CAS Registry Number NA


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + CFT1946 CFT1946 Cetuximab 0 1
CFT1946 CFT1946 1 1
CFT1946 + Trametinib CFT1946 Trametinib 0 1

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