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Drug Name FF-10101
Trade Name
Synonyms FF-10101-01|FF10101|FF 10101
Drug Descriptions

FF-10101 is a second generation and irreversible inhibitor of Flt3, including the internal tandem duplication (FLT3-ITD) and known resistance mutations (D835Y, Y842C, Y842H, or F691L) and also inhibits Kit and Csf1r (Fms) (PMID: 29187377, PMID: 32722298)

DrugClasses CSF1R Inhibitor 28 FLT3 Inhibitor 66 KIT Inhibitor 57
CAS Registry Number 1472797-69-5
NCIT ID C137988


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Therapy Name Drugs Efficacy Evidence Clinical Trials
FF-10101 FF-10101 50 1
FF-10101 + Trametinib FF-10101 Trametinib 2 0

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