Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name BI2536
Trade Name
Synonyms BI 2536|BI-2536
Drug Descriptions

BI2536 inhibits polo-like kinase 1 (PLK1), which disrupts mitosis and induces apoptosis in tumor cells (PMID: 30414309, PMID: 32486290).

DrugClasses PLK1 Inhibitor 17
CAS Registry Number 755038-02-9
NCIT ID C49091


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
BI2536 BI2536 1 0
BI2536 + Metformin BI2536 Metformin 0 0
BI2536 + PD-0325901 BI2536 PD-0325901 0 0
BI2536 + PLX4720 BI2536 PLX4720 1 0

Additional content available in CKB BOOST