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|Therapy Name||Cetuximab + Cisplatin + Irinotecan|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Cetuximab||Erbitux||IMC-C225||EGFR Antibody 29||Erbitux (cetuximab) is a monoclonal antibody directed against EGFR, which inhibits signal transduction and cell proliferation (PMID: 28695301). Erbitux (cetuximab) is FDA approved for use in head and neck squamous cell carcinoma and KRAS wild-type, EGFR positive colorectal cancer (FDA.gov).|
|Cisplatin||Platinol||CDDP||Chemotherapy - Platinum 6||Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).|
|Irinotecan||Camptosar||CPT-11|Onivyde||TOPO1 inhibitor 8||Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||gastrointestinal system cancer||no benefit||Cetuximab + Cisplatin + Irinotecan||Phase II||Actionable||In a Phase II trial, Erbitux (cetuximab) in combination with IC (irinotecan, cisplatin) demonstrated less efficacy and more toxicity, resulted in an overall response rate of 45.0% (32/71), median overall survival of 8.6 months; and median progression-free survival of 4.9 months in patients with metastatic esophageal or gastroesophageal junction cancers (PMID: 27382098).||27382098|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|