Drug Detail


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Drug Name ABBV-927
Trade Name
Drug Descriptions

ABBV-927 is a monoclonal antibody to TNFRSF5 (CD40), which mimics the binding of the ligand, CD40LG (CD40L), to stimulate proliferation of T-cells and enhance an anti-tumor response (NCI Drug Dictionary).

DrugClasses CD40 Antibody 13
CAS Registry Number NA
NCIT ID C139553


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-181 + ABBV-368 + ABBV-927 ABBV-181 ABBV-368 ABBV-927 0 1
ABBV-181 + ABBV-927 + Carboplatin ABBV-181 ABBV-927 Carboplatin 0 1
ABBV-181 + ABBV-927 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin ABBV-181 ABBV-927 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
ABBV-368 + ABBV-927 ABBV-368 ABBV-927 0 1
ABBV-368 + ABBV-927 + Carboplatin ABBV-368 ABBV-927 Carboplatin 0 1
ABBV-368 + ABBV-927 + Nab-paclitaxel ABBV-368 ABBV-927 Nab-paclitaxel 0 1
ABBV-927 ABBV-927 0 2
ABBV-927 + Carboplatin ABBV-927 Carboplatin 0 1
ABBV-927 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin ABBV-927 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
ABBV-927 + Nivolumab ABBV-927 Nivolumab 0 1

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