Drug Detail


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Drug Name siG12D-LODER
Trade Name
Synonyms siG12D LODER
Drug Descriptions

siG12D-LODER is a biodegradable polymer containing KRAS G12D targeting siRNA (siG12D), which slowly releases siG12D in the tumor after implantation, potentially inducing apoptosis and inhibiting cell migration, and reducing metastasis (PMID: 26009994).

CAS Registry Number NA
NCIT ID C95772


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Erlotinib + Gemcitabine + Oxaliplatin + siG12D-LODER Erlotinib Gemcitabine Oxaliplatin siG12D-LODER 0 0
Fluorouracil + Irinotecan + Oxaliplatin + siG12D-LODER Fluorouracil Irinotecan Oxaliplatin siG12D-LODER 0 0
Gemcitabine + Nab-paclitaxel + siG12D-LODER Gemcitabine Nab-paclitaxel siG12D-LODER 0 1
Gemcitabine + siG12D-LODER Gemcitabine siG12D-LODER 0 0
siG12D-LODER siG12D-LODER 0 0

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