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Drug Name SYM004
Trade Name
Synonyms Symphogen
Drug Descriptions

Symphogen (Sym004) is comprised of two antibodies (Futuximab and Modotuximab) that bind EGFR and prevent ligand binding, which may prevent downstream signaling and result in decreased tumor cell proliferation (PMID: 31959764, PMID: 31679083).

DrugClasses EGFR Antibody 31
CAS Registry Number NA
NCIT ID C91381

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Fluorouracil + Irinotecan + Leucovorin + SYM004 Fluorouracil Irinotecan Leucovorin SYM004 0 1
Nivolumab + SYM004 Nivolumab SYM004 0 1
Radiotherapy + SYM004 Radiotherapy SYM004 0 0
SYM004 SYM004 2 4


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