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|Therapy Name||Irinotecan + Navicixizumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Irinotecan||Camptosar||CPT-11|Onivyde||TOPO1 inhibitor 10||Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).|
|Navicixizumab||OMP-305B83|OMP 305B83|OMP305B83||DLL4 Antibody 6 VEGF Antibody 10||Navicixizumab (OMP-305B83) is a bispecific antibody that binds both DLL4 and VEGF, which inhibits NOTCH and VEGFR signaling and may prevent angiogenesis and tumor growth (PMID: 30229512).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05453825||Phase II||Irinotecan + Navicixizumab Navicixizumab Navicixizumab + Paclitaxel||A Study of Navicixizumab Monotherapy or in Combination in Patients With Select Advanced Solid Tumors||Recruiting||USA||0|