Molecular Profile |
Indication/Tumor Type |
Response Type |
Therapy Name |
Approval Status |
Evidence Type |
Efficacy Evidence |
References |
Unknown unknown
|
Advanced Solid Tumor
|
not applicable |
OMP-305B83
|
Phase I |
Actionable |
In a Phase I trial, OMP-305B83 demonstrated safety and preliminary efficacy in a variety of advanced solid tumor patients, including ovarian, endometrial, breast, and pancreatic (Eur J Can, Vol 69, S35).
|
detail...
|
Unknown unknown
|
Advanced Solid Tumor
|
not applicable |
OMP-305B83
|
Preclinical |
Actionable |
In a preclinical study, OMP-305B83 inhibited cell proliferation of endothelial cells in culture and demonstrated antitumor activity of multiple tumor types in vivo (Mol Cancer Ther December 2015 14; C164).
|
detail...
|
Unknown unknown
|
colon cancer
|
not applicable |
OMP-305B83
|
Preclinical |
Actionable |
In a preclinical study, OMP-305B83 inhibited proliferation of endothelial cells in culture and demonstrated antitumor activity in vivo in multiple solid tumor types, including colon tumors (Mol Cancer Ther December 2015 14; C164).
|
detail...
|