Drug Detail


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Drug Name IGM-8444
Trade Name
Synonyms IGM8444|IGM 8444
Drug Descriptions

IGM-8444 is a multivalent agonistic antibody that targets and activates Death Receptor 5 (TNFRSF10B), potentially resulting in increased cytotoxicity and apoptosis, and inhibition of tumor growth (Journal of Clinical Oncology 2020 38:15_suppl, 3595; Cancer Res 2020;80(16 Suppl):Abstract nr 518).

CAS Registry Number NA


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + IGM-8444 + Irinotecan + Leucovorin Bevacizumab Fluorouracil IGM-8444 Irinotecan Leucovorin 0 1
Fluorouracil + IGM-8444 + Irinotecan + Leucovorin Fluorouracil IGM-8444 Irinotecan Leucovorin 0 1
IGM-8444 IGM-8444 0 1

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