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MM-151 is a combination of three human monoclonal antibodies targeting distinct, non-overlapping epitopes of epidermal growth factor receptor (EGFR), thereby preventing the binding of ligands and inhibiting EGFR-ERK-mediated signaling (PMID: 26843189).
|DrugClasses||EGFR Antibody 30|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Fluorouracil + Irinotecan + Leucovorin + MM-151||Fluorouracil Irinotecan Leucovorin MM-151||0||1|