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Drug Name RRx-001
Trade Name
Drug Descriptions

RRx-001 is a nitric oxide donor that is activated by hypoxia, leading to increased oxygen level in tumor and sensitizes tumor to radiotherapy (PMID: 26164533, PMID: 32169409).

CAS Registry Number 925206-65-1
NCIT ID C97130


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Etoposide + RRx-001 Carboplatin Etoposide RRx-001 0 1
Cisplatin + Etoposide + RRx-001 Cisplatin Etoposide RRx-001 0 1
Cisplatin + RRx-001 Cisplatin RRx-001 0 1
Irinotecan + RRx-001 Irinotecan RRx-001 0 1
Irinotecan + RRx-001 + Temozolomide Irinotecan RRx-001 Temozolomide 0 1
Radiotherapy + RRx-001 + Temozolomide RRx-001 Radiotherapy Temozolomide 0 0
RRx-001 RRx-001 0 4
RRx-001 + Temozolomide RRx-001 Temozolomide 0 1

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