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|Therapy Name||Irinotecan + KU-59403|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Irinotecan||Camptosar||CPT-11|Onivyde||TOPO1 inhibitor 10||Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).|
|KU-59403||KU59403|KU 59403||ATM Inhibitor 11||KU-59403 is an ATM inhibitor, which upon inhibition of Atm may lead to increased sensitivity to chemotherapuetic agents such as those inducing double strand breaks, and radiotherapy, subsequently resulting in cytotoxicity and antitumor activity (PMID: 23512991).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|