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|Therapy Name||Letrozole + Taselisib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Letrozole||Femara||Letrozol||Aromatase Inhibitor 3||Femara (letrozole) is an aromatase inhibitor, which inhibits estrogen synthesis, and is approved for postmenopausal women with hormone receptor positive breast cancer (FDA.gov).|
|Taselisib||RG7606|GDC-0032|RG-7604|RO5537381||PIK3CA inhibitor 16 PIK3CD inhibitor 24 PIK3CG inhibitor 8||Taselisib (GDC-0032) is a beta isoform-sparing PI3K inhibitor, with greater activity against oncogenic mutants of PIK3CA (PMID: 23662903, PMID: 31439579).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA mutant||breast cancer||sensitive||Letrozole + Taselisib||Phase Ib/II||Actionable||In a Phase Ib trial, Taselisib (GDC-0032) and Femara (letrozole) combination therapy resulted in an overall response rate of 38% in breast cancer patients with PIK3CA mutations, compared to 9% in patients with wild-type PIK3CA (Cancer Res May 1, 2015 75; PD5-2).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|