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Drug Name RO6839921
Trade Name
Synonyms RO-6839921
Drug Descriptions

RO6839921 is a pegylated prodrug of idasanutlin that binds to MDM2 and inhibits its interaction with p53, preventing degradation of p53, thereby potentially resulting in restoration of wild-type p53 activity and apoptosis of tumor cells (PMID: 31734832, PMID: 32020437).

DrugClasses MDM2 Inhibitor 20
CAS Registry Number NA
NCIT ID C114980

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cytarabine + RO6839921 Cytarabine RO6839921 1 0
Pegylated liposomal-doxorubicin + RO6839921 Pegylated liposomal-doxorubicin RO6839921 1 0
RO6839921 RO6839921 2 1


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