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Drug Name | Indoximod |
Trade Name | |
Synonyms | D-1MT|1-MT|NLG-8189 |
Drug Descriptions |
Indoximod (D-1MT) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 26033215, PMID: 17234791, PMID: 32637034). |
DrugClasses | IDO1 Inhibitor 12 Immune Checkpoint Inhibitor 141 |
CAS Registry Number | 110117-83-4 |
NCIT ID | C71535 |