Drug Detail


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Drug Name Indoximod
Trade Name
Synonyms D-1MT|1-MT|NLG-8189
Drug Descriptions

Indoximod (D-1MT) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 26033215, PMID: 17234791, PMID: 32637034).

DrugClasses IDO1 Inhibitor 12 Immune Checkpoint Inhibitor 149
CAS Registry Number 110117-83-4
NCIT ID C71535


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ad.p53-DC vaccine + Indoximod Ad.p53-DC vaccine Indoximod 0 1
Cyclophosphamide + Etoposide + Ibrutinib + Indoximod Cyclophosphamide Etoposide Ibrutinib Indoximod 0 1
Cyclophosphamide + Etoposide + Indoximod Cyclophosphamide Etoposide Indoximod 0 1
Cytarabine + Idarubicin + Indoximod Cytarabine Idarubicin Indoximod 0 1
Docetaxel + Indoximod Docetaxel Indoximod 0 1
Indoximod Indoximod 0 6
Indoximod + Lomustine + Temozolomide Indoximod Lomustine Temozolomide 0 1
Indoximod + Nivolumab Indoximod Nivolumab 0 1
Indoximod + Pembrolizumab Indoximod Pembrolizumab 0 1
Indoximod + Temozolomide Indoximod Temozolomide 0 1

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