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|Therapy Name||Ibrutinib + JNJ-67856633|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ibrutinib||Imbruvica||PCI-32765||BTK inhibitor 33 EGFR Inhibitor (Pan) 57 HER2 Inhibitor 39||Imbruvica (ibrutinib) is a selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK), which promotes apoptosis and inhibits B-cell mediated signaling pathways, and has additional activity against ERBB2 (HER2) and EGFR (PMID: 20615965, PMID: 21422473, PMID: 27678331). Imbruvica (Ibrutinib) is FDA approved for use in patients with mantle cell lymphoma, CLL/SLL and CLL/SLL with del 17p, Waldenstroem’s macroglobulinemia, marginal zone lymphoma, and in combination with Rituxan (rituximab) for untreated CLL/SLL (FDA.gov).|
|JNJ-67856633||JNJ67856633|JNJ 67856633||JNJ-67856633 is an inhibitor that blocks the activity of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), resulting in decreased NF-kappaB and JAK/STAT signaling, potentially leading to increased apoptosis and decreased growth of MALT1-expressing tumor cells (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04876092||Phase I||Ibrutinib + JNJ-67856633||A Study of the MALT1 Inhibitor JNJ-67856633 and Ibrutinib in B-cell NHL and CLL||Active, not recruiting||FRA||3|