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|Therapy Name||Venetoclax + VU661013|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|VU661013||MCL1 Inhibitor 18||VU661013 is a selective inhibitor of MCL1, which prevents Mcl1 from interacting with Bim, thereby potentially inducing apoptosis and inhibiting cell proliferation (PMID: 30185627, PMID: 31595181).|
|Venetoclax||Venclexta||ABT-199|RG7601|GDC-0199|ABT119|Venclyxto||BCL2 inhibitor 25||Venclexta (venetoclax) is a BH3-mimetic that binds to and inhibits BCL2, resulting in increased tumor cell apoptosis (PMID: 26589495, PMID: 25048785). Venclexta (venetoclax) is FDA approved for use in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), and in combination with chemotherapy in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|