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|Therapy Name||Autologous alpha-DC1/TBVA vaccine + Cabozantinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Autologous alpha-DC1/TBVA vaccine||Autologous alpha-DC1/TBVA vaccine is comprised of patient-derived dendritic cells loaded with tumor blood vessel antigen (TBVA)-derived peptides, which may lead to increased antitumor immune response (PMID: 34782430).|
|Cabozantinib||Cometriq||Cabometyx|Cabozantinib-s-malate|XL184||AXL Inhibitor 29 FLT3 Inhibitor 61 KIT Inhibitor 55 MET Inhibitor 56 RET Inhibitor 48 ROS1 Inhibitor 19 VEGFR2 Inhibitor 36||Cometriq (Cabometyx, cabozantinib) inhibits several receptor tyrosine kinases, including VEGFR2, FLT3, AXL, MET, RET, ROS1 fusions, and c-KIT (PMID: 27370605, PMID: 21926191). Cometriq (cabozantinib) is FDA approved for use in patients with medullary thyroid cancer, Cabometyx (cabozantinib) is FDA approved for use in patients with advanced renal cell carcinoma, hepatocellular carcinoma previously treated with sorafenib, adult and pediatric patients 12 years and older with locally advanced or metastatic differentiated thyroid cancer, and in combination with Opdivo (nivolumab) in patients with advanced renal cell carcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05127824||Phase II||Autologous alpha-DC1/TBVA vaccine + Cabozantinib||Autologous Dendritic Cell Vaccine in Kidney Cancer||Not yet recruiting||USA||0|