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| NCT ID | NCT04003636 |
| Title | Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966) (KEYNOTE-966) |
| Acronym | KEYNOTE-966 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | NZL | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham Comprehensive Cancer Ctr ( Site 0016) | Birmingham | Alabama | 35294 | United States | Details | |
| University of California San Diego Moores Cancer Center ( Site 0008) | La Jolla | California | 92093-0698 | United States | Details | |
| UCLA Hematology/Oncology - Santa Monica ( Site 0014) | Los Angeles | California | 90404 | United States | Details | |
| University of California - San Francisco ( Site 0030) | San Francisco | California | 94158 | United States | Details | |
| University of Colorado Hospital ( Site 0011) | Aurora | Colorado | 80045 | United States | Details | |
| Hartford Hospital ( Site 0057) | Hartford | Connecticut | 06102 | United States | Details | |
| Yale University ( Site 0053) | New Haven | Connecticut | 06510 | United States | Details | |
| Winship Cancer Institute of Emory University ( Site 0013) | Atlanta | Georgia | 30322-1013 | United States | Details | |
| Northwest Georgia Oncology Centers PC ( Site 0045) | Marietta | Georgia | 30060 | United States | Details | |
| Decatur Memorial Hospital ( Site 0056) | Decatur | Illinois | 62526 | United States | Details | |
| Winthrop University Hospital ( Site 0059) | Mineola | New York | 11501 | United States | Details | |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0038) | New York | New York | 10016 | United States | Details | |
| Columbia University/Herbert Irving Cancer Center ( Site 0009) | New York | New York | 10032 | United States | Details | |
| University of Oklahoma- Stephenson Oklahoma Cancer Center ( Site 0055) | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| OHSU Center for Health & Healing ( Site 0044) | Portland | Oregon | 97239 | United States | Details | |
| Charleston Oncology ( Site 0042) | Charleston | South Carolina | 29414 | United States | Details | |
| Saint Francis Health System ( Site 0051) | Greenville | South Carolina | 29607 | United States | Details | |
| Blue Ridge Cancer Care ( Site 0033) | Roanoke | Virginia | 24014 | United States | Details | |
| CEMIC ( Site 0581) | Buenos Aires | Caba | C1431FWO | Argentina | Details | |
| Fundacion Favaloro ( Site 0578) | Ciudad de Buenos Aires | Caba | C1093AAS | Argentina | Details | |
| Centro Medico San Roque ( Site 0579) | San Miguel de Tucuman | Tucuman | T4000IAK | Argentina | Details | |
| Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0580) | Caba | C1264AAA | Argentina | Details | ||
| Centro Oncologico Riojano Integral ( Site 0584) | La Rioja | F5300COE | Argentina | Details | ||
| Liverpool Hospital ( Site 0707) | Liverpool | New South Wales | 2170 | Australia | Details | |
| Mid North Coast Cancer Institute ( Site 0708) | Port Macquarie | New South Wales | 2444 | Australia | Details | |
| Gallipoli Medical Research Foundation ( Site 0705) | Brisbane | Queensland | 4120 | Australia | Details | |
| Eastern Health ( Site 0704) | Box Hill | Victoria | 3128 | Australia | Details | |
| Western Health-Sunshine Hospital ( Site 0709) | St Albans | Victoria | 3021 | Australia | Details | |
| UZA University Hospital Antwerp ( Site 0202) | Edegem | Antwerpen | 2650 | Belgium | Details | |
| Saint-Luc UCL ( Site 0200) | Brussels | Bruxelles-Capitale, Region De | 1200 | Belgium | Details | |
| Erasme Hospital ( Site 0204) | Bruxelles | Bruxelles-Capitale, Region De | 1070 | Belgium | Details | |
| Grand Hopital de Charleroi ( Site 0206) | Charleroi | Hainaut | 6000 | Belgium | Details | |
| CHU de Liege ( Site 0201) | Liège | Liege | 4000 | Belgium | Details | |
| UZ Gent ( Site 0203) | Gent | Oost-Vlaanderen | 9000 | Belgium | Details | |
| UZ Leuven ( Site 0205) | Leuven | Vlaams-Brabant | 3000 | Belgium | Details | |
| Oncobio Servicos de Saude SA ( Site 0604) | Nova Lima | Minas Gerais | 34000-000 | Brazil | Details | |
| Hospital de Caridade de Ijui ( Site 0602) | Ijui | Rio Grande Do Sul | 98700-000 | Brazil | Details | |
| Associacao Hospitalar Moinhos de Vento ( Site 0599) | Porto Alegre | Rio Grande Do Sul | 90035-001 | Brazil | Details | |
| Hospital de Clinicas de Porto Alegre ( Site 0610) | Porto Alegre | Rio Grande Do Sul | 90035-903 | Brazil | Details | |
| Hospital Nossa Senhora da Conceicao ( Site 0601) | Porto Alegre | Rio Grande Do Sul | 91350-200 | Brazil | Details | |
| Instituto COI de Pesquisa Educacao e Gestao ( Site 0606) | Rio de Janeiro | 22793-080 | Brazil | Details | ||
| Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0607) | Sao Paulo | 01246-000 | Brazil | Details | ||
| Hospital Paulistano - Amil Clinical Research ( Site 0603) | Sao Paulo | 01321-001 | Brazil | Details | ||
| Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0609) | Sao Paulo | 01321-001 | Brazil | Details | ||
| A.C. Camargo Cancer Center ( Site 0600) | Sao Paulo | 01509-900 | Brazil | Details | ||
| Tom Baker Cancer Centre ( Site 0184) | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Cross Cancer Institute ( Site 0183) | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0182) | Hamilton | Ontario | L8V5C2 | Canada | Details | |
| Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0180) | Montreal | Quebec | H2X 3E4 | Canada | Details | |
| McGill University Health Centre ( Site 0179) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Centro Investigación del Cáncer James Lind ( Site 0622) | Temuco | Araucania | 4780000 | Chile | Details | |
| IC La Serena Research ( Site 0630) | La Serena | Coquimbo | 1720430 | Chile | Details | |
| Servicios Medicos Urumed ( Site 0621) | Rancagua | Lbtdr Gen Bernardo O Higgins | 2852424 | Chile | Details | |
| Fundacion Arturo Lopez Perez FALP ( Site 0623) | Santiago | Region M. De Santiago | 7500921 | Chile | Details | |
| Sociedad Oncovida S.A. ( Site 0626) | Santiago | Region M. De Santiago | 7510032 | Chile | Details | |
| Pontificia Universidad Catolica de Chile ( Site 0620) | Santiago | Region M. De Santiago | 8330032 | Chile | Details | |
| Anhui Provincial Hospital ( Site 0140) | Hefei | Anhui | 230001 | China | Details | |
| Beijing Cancer Hospital ( Site 0138) | Beijing | Beijing | 100036 | China | Details | |
| Peking Union Medical College Hospital ( Site 0150) | Beijing | Beijing | 100730 | China | Details | |
| First Affiliated Hospital of The Third Military Medical University ( Site 0130) | Chongqing | Chongqing | 400038 | China | Details | |
| Fujian Provincial Cancer Hospital ( Site 0154) | Fuzhou | Fujian | 350014 | China | Details | |
| 900 Hospital of the Joint ( Site 0137) | Fuzhou | Fujian | 350025 | China | Details | |
| Guangdong Provincial People s Hospital ( Site 0161) | Guangzhou | Guangdong | 510080 | China | Details | |
| The Third Xiangya Hospital of Central South University ( Site 0157) | Changsha | Hainan | 410013 | China | Details | |
| Harbin Medical University Cancer Hospital ( Site 0133) | Harbin | Heilongjiang | 610000 | China | Details | |
| Hunan Provincial People Hospital ( Site 0142) | Changsha | Hunan | 410005 | China | Details | |
| Hunan Cancer Hospital ( Site 0132) | Changsha | Hunan | 410013 | China | Details | |
| The 81st Hospital of PLA ( Site 0128) | Nanjing | Jiangsu | 210031 | China | Details | |
| The First Hospital of Jilin University ( Site 0131) | Chanchun | Jilin | 130021 | China | Details | |
| Zhongshan Hospital Fudan University ( Site 0129) | Shanghai | Shanghai | 200032 | China | Details | |
| Renji Hospital Shanghai Jiaotong University School of Medicine ( Site 0158) | Shanghai | Shanghai | 200127 | China | Details | |
| Fudan University Shanghai Cancer Center ( Site 0160) | Shanghai | Shanghai | 201315 | China | Details | |
| Tangdu Hospital ( Site 0146) | XI An | Shanxi | 710038 | China | Details | |
| The First Affiliated Hospital of Xi an Jiaotong University ( Site 0145) | XI An | Shanxi | 710048 | China | Details | |
| West China Hospital of Sichuan University ( Site 0147) | Chengdu | Sichuan | 610041 | China | Details | |
| Tianjin Medical University Cancer Institute & Hospital ( Site 0155) | Tianjin | Tianjin | 300060 | China | Details | |
| The First Affiliated Hospital Zhejiang University ( Site 0136) | Hangzhou | Zhejiang | 310003 | China | Details | |
| Zhejiang Cancer Hospital ( Site 0134) | Hangzhou | Zhejiang | 310022 | China | Details | |
| CHU Bordeaux Haut-Leveque Centre Francois Magendie ( Site 0245) | Pessac Cedex | Gironde | 33604 | France | Details | |
| A.P.H. Paris, Hopital Beaujon ( Site 0247) | Clichy | Hauts-de-Seine | 92110 | France | Details | |
| CHU de Montpellier - Hopital Saint-Eloi ( Site 0248) | Montpellier | Herault | 34295 | France | Details | |
| Centre Eugene Marquis ( Site 0242) | Rennes | Ille-et-Vilaine | 35042 | France | Details | |
| CHU Clermont-Ferrand - Site Estaing ( Site 0249) | Clermont-Ferrand | Puy-de-Dome | 63003 | France | Details | |
| Gustave Roussy ( Site 0244) | Villejuif | Val-de-Marne | 94805 | France | Details | |
| Universitaetsklinikum Ulm ( Site 0267) | Ulm | Baden-Wurttemberg | 89081 | Germany | Details | |
| Klinikum der Ludwig - Maximilian Universitat Munchen ( Site 0264) | Muenchen | Bayern | 81377 | Germany | Details | |
| Krankenhaus Nordwest ( Site 0266) | Frankfurt | Hessen | 60488 | Germany | Details | |
| Medizinische Hochschule Hannover ( Site 0265) | Hannover | Niedersachsen | 30625 | Germany | Details | |
| Universitaetsklinikum Aachen AOER ( Site 0275) | Aachen | Nordrhein-Westfalen | 52074 | Germany | Details | |
| Universitaetsklinikum Essen ( Site 0273) | Essen | Nordrhein-Westfalen | 45147 | Germany | Details | |
| Universitaetsklinikum Koeln ( Site 0274) | Koeln | Nordrhein-Westfalen | 50937 | Germany | Details | |
| Universitaetsklinikum Magdeburg A.o.R. ( Site 0271) | Magdeburg | Sachsen-Anhalt | 39120 | Germany | Details | |
| Staedtisches Klinikum Dresden ( Site 0272) | Dresden | Sachsen | 01067 | Germany | Details | |
| Charite - Universtitatsmedizin Berlin CCM ( Site 0269) | Berlin | 10117 | Germany | Details | ||
| Universitaetsklinikum Hamburg-Eppendorf ( Site 0268) | Hamburg | 20246 | Germany | Details | ||
| Pamela Youde Nethersole Eastern Hospital ( Site 0857) | Hong Kong | Hong Kong | Details | |||
| Prince of Wales Hospital ( Site 0855) | Hong Kong | Hong Kong | Details | |||
| Princess Margaret Hospital. ( Site 0856) | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital ( Site 0851) | Hong Kong | Hong Kong | Details | |||
| Queen Elizabeth Hospital. ( Site 0854) | Kowloon | Hong Kong | Details | |||
| Cork University Hospital ( Site 0538) | Cork | T12 DC4A | Ireland | Details | ||
| Bon Secours Hospital ( Site 0526) | Cork | T12 DV56 | Ireland | Details | ||
| Tallaght University Hospital ( Site 0522) | Dublin | D24 NROA | Ireland | Details | ||
| St Vincents University Hospital ( Site 0521) | Dublin | DO4 YN63 | Ireland | Details | ||
| Rambam Medical Center ( Site 0308) | Haifa | 3109601 | Israel | Details | ||
| Hadassah Ein Karem - Sharett Institute of Oncology ( Site 0309) | Jerusalem | 9112001 | Israel | Details | ||
| Rabin Medical Center ( Site 0307) | Petah Tikva | 4941492 | Israel | Details | ||
| Sourasky Medical Center ( Site 0306) | Tel Aviv | 6423906 | Israel | Details | ||
| Universita Cattolica del Sacro Cuore - Policlinico Gemelli ( Site 0329) | Rome | Abruzzo | 00168 | Italy | Details | |
| Policlinico S. Orsola-Malpighi ( Site 0333) | Bologna | 40138 | Italy | Details | ||
| A.O. di Rilievo Nazionale e di alta Specializzazione Garibaldi ( Site 0330) | Catania | 95124 | Italy | Details | ||
| ASST Grande Ospedale Metropolitano Niguarda ( Site 0332) | Milano | 20162 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Pisana ( Site 0326) | Pisa | 56127 | Italy | Details | ||
| Policlinico Universitario Campus Biomedico ( Site 0328) | Roma | 00128 | Italy | Details | ||
| Azienda Ospedaliera Universitaria di Verona ( Site 0334) | Verona | 37134 | Italy | Details | ||
| Aichi Cancer Center Hospital ( Site 0080) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| National Cancer Center Hospital East ( Site 0081) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| Kobe City Medical Center General Hospital ( Site 0087) | Kobe | Hyogo | 650-0047 | Japan | Details | |
| Kagawa University Hospital ( Site 0086) | Kita-gun | Kagawa | 761-0793 | Japan | Details | |
| Kanagawa Cancer Center ( Site 0079) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Osaka University Hospital ( Site 0085) | Suita | Osaka | 565-0871 | Japan | Details | |
| Kyorin University Hospital ( Site 0077) | Mitaka | Tokyo | 181-8611 | Japan | Details | |
| National Hospital Organization Kyushu Cancer Center ( Site 0078) | Fukuoka | 811-1395 | Japan | Details | ||
| Kyoto University Hospital ( Site 0083) | Kyoto | 606-8507 | Japan | Details | ||
| Osaka International Cancer Institute ( Site 0084) | Osaka | 541-8567 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 0082) | Tokyo | 135-8550 | Japan | Details | ||
| Chonnam National University Hwasun Hospital ( Site 0837) | Hwasun Gun | Jeonranamdo | 58128 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 0833) | Seongnam-si | Kyonggi-do | 13605 | Korea, Republic of | Details | |
| CHA Bundang Medical Center CHA University ( Site 0835) | Seongnam | Kyonggi-do | 13496 | Korea, Republic of | Details | |
| Ajou University Hospital, Clinical Research Center ( Site 0838) | Suwon-si | Kyonggi-do | 16499 | Korea, Republic of | Details | |
| Kyungpook National University Chilgok Hospital ( Site 0834) | Daegu | Taegu-Kwangyokshi | 41404 | Korea, Republic of | Details | |
| Chungnam National University Hospital ( Site 0840) | Daejeon | Taejon-Kwangyokshi | 35015 | Korea, Republic of | Details | |
| Severance Hospital Yonsei University Health System ( Site 0836) | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center ( Site 0830) | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 0831) | Seoul | 06351 | Korea, Republic of | Details | ||
| The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0839) | Seoul | 06591 | Korea, Republic of | Details | ||
| Korea University Guro Hospital ( Site 0832) | Seoul | 08308 | Korea, Republic of | Details | ||
| Hospital Sultan Ismail ( Site 0772) | Johor Bahru | Johor | 81100 | Malaysia | Details | |
| University Malaya Medical Centre ( Site 0770) | Lembah Pantai | Kuala Lumpur | 59100 | Malaysia | Details | |
| Hospital Pulau Pinang ( Site 0773) | Georgetown | Pulau Pinang | 10990 | Malaysia | Details | |
| Institut Kanser Negara - National Cancer Institute ( Site 0767) | Putrajaya | Wilayah Persekutuan Putrajaya | 62250 | Malaysia | Details | |
| Hospital Kuala Lumpur ( Site 0768) | Kuala Lumpur | 50586 | Malaysia | Details | ||
| Pantai Hospital Kuala Lumpur ( Site 0771) | Kuala Lumpur | 59100 | Malaysia | Details | ||
| Maastricht University Medical Centre ( Site 0347) | Maastricht | Limburg | 6229 HX | Netherlands | Details | |
| AMC ( Site 0348) | Amsterdam | Noord-Holland | 1105 AZ | Netherlands | Details | |
| Erasmus University Medical Center ( Site 0352) | Rotterdam | Zuid-Holland | 3015 GD | Netherlands | Details | |
| UMCG ( Site 0349) | Groningen | 9713 GZ | Netherlands | Details | ||
| Universitair Medisch Centrum Utrecht ( Site 0351) | Utrecht | 3584 CX | Netherlands | Details | ||
| Auckland City Hospital ( Site 0725) | Auckland | 1023 | New Zealand | Details | ||
| Hospital Universitario General de Asturias ( Site 0434) | Oviedo | Asturias | 33011 | Spain | Details | |
| Hospital General Universitari Vall d Hebron ( Site 0432) | Barcelona | 08035 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon ( Site 0433) | Madrid | 28009 | Spain | Details | ||
| Hospital Universitario HM Sanchinarro ( Site 0435) | Madrid | 28050 | Spain | Details | ||
| Hospital Regional Universitario Carlos Haya ( Site 0431) | Malaga | 29010 | Spain | Details | ||
| Taipei Veterans General Hospital ( Site 0861) | Taipei, | Taipei | 112 | Taiwan | Details | |
| Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0865) | Kaohsiung | 833 | Taiwan | Details | ||
| China Medical University Hospital ( Site 0862) | Taichung | 40447 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 0864) | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 0860) | Taipei | 10048 | Taiwan | Details | ||
| Koo Foundation Sun Yat-Sen Cancer Center ( Site 0863) | Taipei | 112 | Taiwan | Details | ||
| Chang Gung Medical Foundation. Linkou ( Site 0853) | Taoyuan | 333 | Taiwan | Details | ||
| King Chulalongkorn Memorial Hospital ( Site 0884) | Bangkok | Krung Thep Maha Nakhon | 10330 | Thailand | Details | |
| Ramathibodi Hospital. ( Site 0889) | Bangkok | Krung Thep Maha Nakhon | 10400 | Thailand | Details | |
| Siriraj Hospital ( Site 0888) | Bangkok | Krung Thep Maha Nakhon | 10700 | Thailand | Details | |
| Sunpasithiprasong Hospital ( Site 0883) | Ubonratchathani | Ubon Ratchathani | 34000 | Thailand | Details | |
| Maharaj Nakorn Chiang Mai Hospital ( Site 0887) | Chiang Mai | 50200 | Thailand | Details | ||
| Srinagarind Hospital ( Site 0885) | Khon Kaen | 40002 | Thailand | Details | ||
| Udon Thani Cancer Hospital ( Site 0886) | Udon Thani | 41330 | Thailand | Details | ||
| Inonu Universitesi Medical Fakultesi ( Site 0501) | Malatya | Adana | 44280 | Turkey | Details | |
| Baskent University Adana Training Hospital ( Site 0499) | Adana | 01250 | Turkey | Details | ||
| Hacettepe University Faculty of Medicine ( Site 0498) | Ankara | 06100 | Turkey | Details | ||
| Abdurrahman Yurtaslan Onkoloji Hastanesi ( Site 0494) | Ankara | 06200 | Turkey | Details | ||
| Gazi Universitesi Tip Fakultesi ( Site 0496) | Ankara | 06500 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0506) | Istanbul | 34098 | Turkey | Details | ||
| Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0495) | Istanbul | 34722 | Turkey | Details | ||
| Izmir Medical Park Hospital Department of Medical Oncology ( Site 0502) | Izmir | 35520 | Turkey | Details | ||
| Erciyes Universitesi Tip Fakultesi ( Site 0500) | Kayseri | 38039 | Turkey | Details | ||
| Aberdeen Royal Infirmary ( Site 0529) | Aberdeen | Aberdeen City | AB252ZN | United Kingdom | Details | |
| Royal Free London NHS Foundation Trust ( Site 0520) | London | London, City Of | NW3 2QG | United Kingdom | Details | |
| Royal Marsden Hospital ( Site 0536) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
| Imperial College Healthcare NHS Trust - Hammersmith Hospital ( Site 0525) | London | London, City Of | W12 0HS | United Kingdom | Details | |
| Royal Marsden NHS Foundation Trust ( Site 0535) | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| Belfast City Hospital ( Site 0517) | Belfast | BT9 7AB | United Kingdom | Details | ||
| University Hospital Coventry and Warwickshire NHS Trust ( Site 0518) | Coventry | CV2 2DX | United Kingdom | Details | ||
| The Christie NHS Foundation Trust ( Site 0537) | Manchester | M20 4BX | United Kingdom | Details |