Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FGFR2 fusion Derazantinib intrahepatic cholangiocarcinoma sensitive detail...
IDH1 R132S Dasatinib intrahepatic cholangiocarcinoma sensitive detail...
IDH1 R132S Saracatinib intrahepatic cholangiocarcinoma sensitive detail...
IDH1 R132C Saracatinib intrahepatic cholangiocarcinoma sensitive detail...
IDH1 R132C Dasatinib intrahepatic cholangiocarcinoma sensitive detail...
IDH2 R172K KRAS G12D Dasatinib intrahepatic cholangiocarcinoma sensitive detail...
IDH2 R172K KRAS G12D Saracatinib intrahepatic cholangiocarcinoma sensitive detail...
IDH1 R132C SRC T341I Dasatinib intrahepatic cholangiocarcinoma resistant detail...
FGFR2 F276C BGJ398 intrahepatic cholangiocarcinoma predicted - sensitive detail...
FGFR2-SORBS1 FGFR2 K660M FGFR2 K715R BGJ398 intrahepatic cholangiocarcinoma resistant detail...
FGFR2-SORBS1 FGFR2 K660M FGFR2 K715R TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-SORBS1 BGJ398 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-SORBS1 FGFR2 V565F TAS-120 intrahepatic cholangiocarcinoma resistant detail...
FGFR2-ZMYM4 BGJ398 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-ZMYM4 FGFR2 V565F FGFR2 K660M FGFR2 E566A FGFR2 N550H FGFR2 N550K BGJ398 intrahepatic cholangiocarcinoma resistant detail...
FGFR2-ZMYM4 FGFR2 V565F FGFR2 K660M FGFR2 E566A FGFR2 N550H FGFR2 N550K TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-ZMYM4 FGFR2 V563L TAS-120 intrahepatic cholangiocarcinoma resistant detail...
FGFR2-INA Debio 1347 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-INA FGFR2 H683L FGFR2 L618V FGFR2 N550H FGFR2 N550T FGFR2 M538I Debio 1347 intrahepatic cholangiocarcinoma resistant detail...
FGFR2-INA FGFR2 H683L FGFR2 L618V FGFR2 N550H FGFR2 N550T FGFR2 M538I TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-INA FGFR2 V565L FGFR2 E566A TAS-120 intrahepatic cholangiocarcinoma resistant detail...
FGFR2-NRAP BGJ398 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-NRAP TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2-NRAP FGFR2 N550K TAS-120 intrahepatic cholangiocarcinoma resistant detail...
FGFR2-KIAA1217 TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 M538I BGJ398 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 N550H BGJ398 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 E566A BGJ398 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 H683L BGJ398 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 N550K BGJ398 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 V565F BGJ398 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 L618V BGJ398 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 K660M BGJ398 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 K715R BGJ398 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 K715R Debio 1347 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 M538I Debio 1347 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 N550H Debio 1347 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 V565F Debio 1347 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 E566A Debio 1347 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 H683L Debio 1347 intrahepatic cholangiocarcinoma decreased response detail...
FGFR2 fusion FGFR2 N550K Debio 1347 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 L618V Debio 1347 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 K660M Debio 1347 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 V565F TAS-120 intrahepatic cholangiocarcinoma resistant detail...
FGFR2 fusion FGFR2 K715R TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 M538I TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 N550H TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 N550K TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 E566A TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 L618V TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 K660M TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
FGFR2 fusion FGFR2 H683L TAS-120 intrahepatic cholangiocarcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT02428855 Phase II Dasatinib Phase II Trial of Dasatinib in Patients With Isocitrate Dehydrogenase (IDH)-Mutant Advanced Intrahepatic Cholangiocarcinoma Completed
NCT02834013 Phase 0 Ipilimumab + Nivolumab Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting
NCT02834780 Phase I H3B-6527 Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Subjects With Advanced Hepatocellular Carcinoma Recruiting
NCT03230318 Phase III Derazantinib ARQ 087 in Subjects With FGFR2 Gene Fusion Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma Recruiting
NCT03684811 Phase Ib/II Cisplatin + FT-2102 + Gemcitabine Azacitidine + FT-2102 FT-2102 FT-2102 + Nivolumab A Study of FT 2102 in Participants With Advanced Solid Tumors and Gliomas With an IDH1 Mutation Recruiting