Molecular Profile Detail


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Profile Name FGFR2 Y376C
Gene Variant Detail

FGFR2 Y376C (gain of function - predicted)

Relevant Treatment Approaches FGFR Inhibitor (Pan) FGFR2 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 Y376C intrahepatic cholangiocarcinoma predicted - sensitive FGFR2 Inhibitor AZD4547 Case Reports/Case Series Actionable In a Phase II (MATCH) trial, AZD4547 treatment resulted in an overall response rate of 10.5% (2/19) in patients with advanced solid tumors harboring FGFR2 or 3 activating single nucleotide variants and a 6-month progression-free survival rate of 6%, including a partial response with 69% reduction in target lesion size and progression-free survival of 9.8 months in a patient with intrahepatic cholangiocarcinoma harboring FGFR2 Y376C (PMID: 32463741; NCT02465060). 32463741