Therapy Detail

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Therapy Name 3HP-2827
Synonyms
Therapy Description

3HP-2827 selectively inhibits FGFR2, potentially resulting in decreased cell proliferation and tumor growth (Cancer Res (2024) 84 (6_Supplement): 1965).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
3HP-2827 3HP 2827|3HP2827 FGFR2 Inhibitor 23 3HP-2827 selectively inhibits FGFR2, potentially resulting in decreased cell proliferation and tumor growth (Cancer Res (2024) 84 (6_Supplement): 1965).

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 amp stomach cancer predicted - sensitive 3HP-2827 Preclinical - Pdx Actionable In a preclinical study, 3HP-2827 treatment demonstrated antitumor activity in a patient-derived xenograft (PDX) model of gastric cancer with FGFR2 amplification (Cancer Res (2024) 84 (6_Supplement): 1965). detail...
FGFR2 N549K endometrial cancer predicted - sensitive 3HP-2827 Preclinical - Cell line xenograft Actionable In a preclinical study, 3HP-2827 treatment demonstrated antitumor activity in a cell line xenograft model of endometrial cancer harboring FGFR2 N549K (Cancer Res (2024) 84 (6_Supplement): 1965). detail...
FGFR2 fusion intrahepatic cholangiocarcinoma predicted - sensitive 3HP-2827 Preclinical - Pdx Actionable In a preclinical study, 3HP-2827 treatment demonstrated antitumor activity and induced tumor regression in a patient-derived xenograft (PDX) model of intrahepatic cholangiocarcinoma harboring an FGFR2 fusion (Cancer Res (2024) 84 (6_Supplement): 1965). detail...
FGFR2 fusion stomach cancer predicted - sensitive 3HP-2827 Preclinical - Pdx Actionable In a preclinical study, 3HP-2827 treatment demonstrated antitumor activity in a patient-derived xenograft (PDX) model of gastric cancer harboring an FGFR2 fusion (Cancer Res (2024) 84 (6_Supplement): 1965). detail...

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06287918 Phase I 3HP-2827 A First-in-human Study of 3HP-2827 in Patients With Unresectable or Metastatic Solid Tumours With FGFR2 Alterations Not yet recruiting USA 0


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