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|Profile Name||FGFR2 H167_N173del|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 H167_N173del||intrahepatic cholangiocarcinoma||predicted - sensitive||Debio 1347||Case Reports/Case Series||Actionable||In a clinical study, Debio 1347 treatment resulted in durable partial response of 11 months in 2 patients with intrahepatic cholangiocarcinoma harboring FGFR2 H167_N173del (J Clin Oncol 38, 2020 (suppl 4; abstr 567)).||detail...|
|FGFR2 H167_N173del||intrahepatic cholangiocarcinoma||predicted - sensitive||Debio 1347||Case Reports/Case Series||Actionable||In a Phase I trial, Debio 1347 treatment led to 51% tumor reduction and a progression-free survival of 13 months in an intrahepatic cholangiocarcinoma patient harboring FGFR2 H167_N173del, which was consistent with inhibition of growth in an intrahepatic cholangiocarcinoma cell line expressing FGFR2 H167_N173del in culture (PMID: 33926920; NCT01948297).||33926920|
|FGFR2 H167_N173del||intrahepatic cholangiocarcinoma||predicted - sensitive||Futibatinib||Preclinical - Cell culture||Actionable||In a preclinical study, Lytgobi (futibatinib) inhibited growth of an intrahepatic cholangiocarcinoma cell line expressing FGFR2 H167_N173del in culture (PMID: 33926920).||33926920|
|FGFR2 H167_N173del||marginal zone lymphoma||predicted - sensitive||Debio 1347||Preclinical - Cell culture||Actionable||In a clinical case study, Debio 1347 treatment in a marginal zone lymphoma patient harboring FGFR2 H167_N173del, who had previously been treated with several lines of therapy, led to a partial response and 36% decrease in tumor burden associated with lymphadenopathy and lung and liver lesions at 16 weeks, with continued response after 7 months (PMID: 33926920).||33926920|