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|Profile Name||FGFR2 I288_E295delinsT|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 I288_E295delinsT||intrahepatic cholangiocarcinoma||predicted - sensitive||Debio 1347||Case Reports/Case Series||Actionable||In a clinical case study, Debio 1347 treatment in an intrahepatic cholangiocarcinoma patient harboring FGFR2 I288_E395delinsT led to a partial response with a 50% decrease in tumor burden, which was ongoing after 24 months (PMID: 33926920).||33926920|