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NCT ID NCT04662255
Title Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) (BRUIN-MCL-321)
Acronym BRUIN-MCL-321
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Loxo Oncology, Inc.
Age Groups: senior | adult
Covered Countries USA | NZL | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS

Facility Status City State Zip Country Details
Alaska Oncology & Hematology, LLC Anchorage Alaska 99508 United States Details
Arizona Oncology Associates, P.C. - HOPE Phoenix Arizona 85016 United States Details
Arizona Oncology Associates, P.C. - HOPE Tucson Arizona 85711 United States Details
St. Joseph Heritage Healthcare Fullerton California 92835 United States Details
The Oncology Institute of Hope and Innovation Long Beach California 90805 United States Details
UCLA Medical Center Los Angeles California 90095 United States Details
Rocky Mountain Cancer Center Aurora Colorado 80012 United States Details
Medical Oncology Hematology Consultants, PA Newark Delaware 19713 United States Details
Florida Cancer Specialists Fort Myers Florida 33901 United States Details
Mayo Clinic in Florida Jacksonville Florida 32224 United States Details
Florida Cancer Specialists Saint Petersburg Florida 33705 United States Details
Florida Cancer Specialists Tallahassee Florida 32308 United States Details
Oncology-Hematology Associates of West Broward Tamarac Florida 33321 United States Details
Florida Cancer Specialists East West Palm Beach Florida 33401 United States Details
University of Kentucky Markey Cancer Center Lexington Kentucky 40504 United States Details
Mercy Health-Paducah Medical Oncology and Hematology Paducah Kentucky 42003 United States Details
Hematology Oncology Clinic Baton Rouge Louisiana 70809 United States Details
Cancer Center Office of Clinical Research New Orleans Louisiana 70112 United States Details
Greenebaum Comprehensive Cancer Center Baltimore Maryland 21201 United States Details
Dana-Farber Cancer Institute Boston Massachusetts 02215 United States Details
University of Michigan Ann Arbor Michigan 48109 United States Details
Karmanos Cancer Institute Detroit Michigan 48201 United States Details
Mayo Clinic Rochester Minnesota 55905 United States Details
Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC Kansas City Missouri 64132 United States Details
Washington University Medical School Saint Louis Missouri 63110 United States Details
University of Nebraska Medical Center Omaha Nebraska 68105 United States Details
Comprehensive Cancer Centers of Nevada Las Vegas Nevada 89169 United States Details
Hematology Oncology Associates Of Northern New Jersey Morristown New Jersey 07960 United States Details
Columbia University Medical Center New York New York 10032 United States Details
Memorial Sloan Kettering Cancer Center New York New York 10065 United States Details
New York Medical College New York New York 10532 United States Details
Messino Cancer Center Asheville North Carolina 28806 United States Details
Levine Cancer Institute Charlotte North Carolina 28204 United States Details
Wake Forest University School of Medicine Winston-Salem North Carolina 27157 United States Details
Oncology Hematology Care Inc Cincinnati Ohio 45236 United States Details
Willamette Valley Cancer Institute & Research Ctr. Eugene Oregon 97401 United States Details
Oregon Oncology Specialists Salem Oregon 97301 United States Details
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15213 United States Details
Sarah Cannon Research Institute SCRI Nashville Tennessee 37203 United States Details
Texas Oncology-Austin Midtown Austin Texas 78705 United States Details
Texas Oncology - Bedford Bedford Texas 76022 United States Details
Texas Oncology - Bayler Charles A. Sammons Cancer Center Houston Texas 75246 United States Details
University of Texas MD Anderson Cancer Center Houston Texas 77030 United States Details
Texas Oncology - McAllen McAllen Texas 78503 United States Details
Texas Oncology - McKinney McKinney Texas 75071 United States Details
Texas Oncology - Sherman Sherman Texas 75090 United States Details
Texas Oncology - Tyler Tyler Texas 75702 United States Details
Huntsman Cancer Institute Salt Lake City Utah 84112 United States Details
University of Virginia Cancer Center Charlottesville Virginia 22908 United States Details
Virginia Cancer Specialists, PC Gainesville Virginia 20155 United States Details
Seattle Cancer Care Alliance Seattle Washington 98109 United States Details
University of Wisconsin Carbone Cancer Center Madison Wisconsin 53705 United States Details
Froedtert Memorial Lutheran Hospital Milwaukee Wisconsin 53226 United States Details
The St. George Hospital Kogarah New South Wales 2217 Australia Details
Flinders Medical Centre Adelaide South Australia 5042 Australia Details
Royal Hobart Hospital Hobart Tasmania 7000 Australia Details
Andrew Lowe Cancer Centre Geelong Victoria 3220 Australia Details
Linear Clinical Research Ltd Nedlands Western Australia WA6009 Australia Details
Royal Perth Hospital Perth Western Australia 6000 Australia Details
Icon Cancer Care - The Wesley Medical Centre Auchenflower 4066 Australia Details
Ordensklinikum Linz GmbH Elisabethinen Linz Oberösterreich 4020 Austria Details
Uniklinikum Salzburg Salzburg Osterreich 5020 Austria Details
Universitair Ziekenhuis Gent Gent 9000 Belgium Details
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg Leuven 3000 Belgium Details
AZ Delta Roeselare 8800 Belgium Details
NOHC- Nucleo de Oncologia e Hematologia do Ceara e Oncovie Fortaleza Ceará 60115-281 Brazil Details
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás Goiânia Goiás 74605-020 Brazil Details
Hospital Sao Domingos São Luís Maranhão 65060-645 Brazil Details
HC-UFPR- Hospital de Clinicas da Universidade Federal do Parana Curitiba Paraná 80060-900 Brazil Details
HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas Campinas Sao Paulo 13060-904 Brazil Details
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia Santo Andre Sao Paulo 09060-870 Brazil Details
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto São José Do Rio Preto São Paulo 15090-000 Brazil Details
INCA - Instituto Nacional de Cancer Rio De Janeiro 20231-050 Brazil Details
Hospital Sao Lucas Copacabana Rio de Janeiro 22061-080 Brazil Details
IEP - Instituto de Ensino e Pesquisas São Lucas Sao Paulo 01236-030 Brazil Details
Irmandade da Santa Casa de Misericordia de Sao Paulo São Paulo 01221-010 Brazil Details
BP A Beneficencia Portuguesa da Sao Paulo São Paulo 01323-001 Brazil Details
A. C. Camargo Cancer Center São Paulo 01509-010 Brazil Details
HC-FMUSP São Paulo 05403-010 Brazil Details
Albert Einstein Sociedade Beneficente Israelita Brasileira São Paulo 05652-900 Brazil Details
Hospital Nove de Julho São Paulo 1409902 Brazil Details
Cross Cancer Institute Edmonton Alberta T6G 1Z2 Canada Details
BC Cancer Vancouver Vancouver British Columbia V5Z 1H6 Canada Details
CancerCare Manitoba Winnipeg Manitoba R3A 1M3 Canada Details
Princess Margaret Cancer Centre Toronto Ontario M4X 1K9 Canada Details
Anhui Provincial Cancer Hospital Hefei Anhui 233004 China Details
Peking University First Hospital Beijing Beijing 100034 China Details
Peking University People's Hospital Beijing Beijing 100044 China Details
Beijing Chaoyang Hospital, Capital Medical University Beijing Beijing 100141 China Details
Peking University Third Hospital Beijing Beijing 100191 China Details
Beijing Cancer hospital Haidian District Beijing 100142 China Details
Fujian Cancer Hospital Fuzhou Fujian 350014 China Details
Cancer Center of Guangzhou Medical University Guangzhou Guangdong 510000 China Details
Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 China Details
Southern Medical University Nanfang Hospital Guangzhou Guangdong 510515 China Details
The First Affiliated Hospital of Henan Science and Technology University Luoyang Henan 471003 China Details
Henan Cancer Hospital Zhengzhou Henan 450008 China Details
Wuhan Union Hospital Wuhan Hubei 430022 China Details
Yichang Central People's Hospital Yichang Hubei 443003 China Details
Hunan Cancer Hospital Changsha Hunan 410013 China Details
The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215066 China Details
The First Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Details
Jilin Cancer Hospital Changchun Jilin 410013 China Details
Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Details
West China Hospital of Sichuan University Chengdu Sichuan 610041 China Details
Tianjin Medical University Cancer Institute and Hospital Tianjin Tianjin 300060 China Details
Affiliated Tumor Hospital of Xinjiang Medical University Urumqi Xinjiang 830002 China Details
Zhejiang Cancer Hospital Hangzhou Zhejiang 310022 China Details
Lishui Municipal Central Hospital Lishui Zhejiang 323000 China Details
Chongqing Cancer Hospital Chongqing 400030 China Details
Fudan University Shanghai Cancer Center Shanghai 200032 China Details
Blood Institute of the Chinese Academy of Medical science Tianjin 300020 China Details
Fakultni nemocnice Brno Brno 62500 Czechia Details
Fakultni nemocnice Hradec Kralove Hradec Kralove 500 05 Czechia Details
Aarhus Universitetshospital, Aarhus Sygehus Aarhus N Jutland DK-8200 Denmark Details
Odense Universitetshospital Odense DK-5000 Denmark Details
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest Bordeaux Aquitaine 33076 France Details
Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen Rouen Seine-Maritime 76038 France Details
CHRU De Tours Tours Tours Cedex 9 37044 France Details
Hopital Saint Vincent De Paul Lille cedex 59020 France Details
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu Nantes Cedex 1 44093 France Details
Groupe Hospitalier Pitie-Salpetriere Paris 75013 France Details
Centre hospitalier universitaire de Haut Leveque Pessac Cedex 33600 France Details
Centre Hospitalier Lyon Sud Pierre Benite Cedex 69495 France Details
Pole Regionalde Cancérologie(CHU de Poitiers) Politiers 86021 France Details
Chu De Nancy Hop D'Adultes De Brabois Vandœuvre-lès-Nancy 54500 France Details
Institut Curie Saint-Cloud Île-de-France 92210 France Details
Universitätsklinikum Ulm Ulm Baden-Württemberg 89081 Germany Details
Klinikum der Universität München Großhadern München Bayern 81377 Germany Details
Universitaetsklinikum Muenster Münster Nordrhein-Westfalen 48149 Germany Details
InVO - Institut für Versorgungsforschung in der Onkologie GbR Koblenz Rhineland-Palatinate 65068 Germany Details
Universitaetsklinikum Schleswig-Holstein - Campus Kiel Kiel Schleswig Holstein 24105 Germany Details
OncoResearch Lerchenfeld GmbH Hamburg 22081 Germany Details
Universitätsmedizin Johannes Gutenberg Universität Mainz Mainz 55131 Germany Details
Universitaetsklinikum Muenster Munster 48149 Germany Details
Pecsi Tudomanyegyetem Klinikai Kozpont Pécs Baranya 7632 Hungary Details
Debreceni Egyetem Debrecen 4032 Hungary Details
St James's Hosptial Dublin Dublin 8 D08 NHY1 Ireland Details
Bnai Zion Medical Center Haifa 3339419 Israel Details
Hadassah Medical Center Jerusalem 9112001 Israel Details
Chaim Sheba Medical Center Ramat Gan Israel Details
Tel Aviv Sourasky Medical Center Tel Aviv 6423906 Israel Details
Presidio Ospedaliero Civile Santi Antonio e Biagio Alessandria AL 15100 Italy Details
Azienda Ospedaliero Universitaria Ospedali Riuniti Torrette Ancona 60020 Italy Details
Irccs Istituto Tumori Giovanni Paolo Ii Viale Orazio Flacco Bari 70124 Italy Details
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola Emilia-Romagna 47014 Italy Details
Ospedale San Raffaele Milano Lombardia 20132 Italy Details
Irccs Crob Rionero in Vulture Potenza 85028 Italy Details
IRCCS - AOU di Bologna Bologna 40138 Italy Details
IRCCS Ospedale Policlinico San Martino Genova 16132 Italy Details
Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte Messina 98158 Italy Details
Ospedale Vincenzo Cervello Palermo 90100 Italy Details
Azienda Ospedaliero Universitaria Pisana Pisa 56126 Italy Details
Ospedale Santa Maria delle Croci Ravenna 48020 Italy Details
Arcispedale Santa Maria Nuova Reggio Emilia 42123 Italy Details
Ospedale di Circolo e Fondazione Macchi Varese Varese 21100 Italy Details
Nagoya Medical Center Nagoya Aichi 460-0001 Japan Details
Nagoya City University Hospital Nagoya Aichi 467-8602 Japan Details
Hokkaido University Hospital Sapporo Hokkaido 060-8648 Japan Details
Kobe City Medical Center General Hospital Kobe Hyogo 650-0047 Japan Details
Kochi Medical School Hospital Nankoku Kochi 783-8505 Japan Details
Tohoku University Hospital Sendai-shi Miyagi 980-8574 Japan Details
Kindai University Hospital Osaka Sayama-shi Osaka 589 8511 Japan Details
Saitama Medical Center Kawagoe Saitama 350-8550 Japan Details
Japanese Foundation for Cancer Research Koto Tokyo 135-8550 Japan Details
NTT Medical Center Tokyo Shinagawa-KU Tokyo 141-8625 Japan Details
Chugoku Central Hospital Hiroshima 720-0001 Japan Details
Kumamoto University Hospital Kumamoto 860-8556 Japan Details
Kyoto Furitsu Medical University Hospital Kyoto-shi 602 8566 Japan Details
Okayama University Hospital Okayama 700-8558 Japan Details
Gachon University Gil Hospital Namdong-gu Incheon-gwangyeoksi [Incheon] 21565 Korea, Republic of Details
Kosin University Gospel Hospital Busan Seogu 49267 Korea, Republic of Details
Seoul National University Hospital Seoul Seoul, Korea 03080 Korea, Republic of Details
Severance Hospital, Yonsei University Health System Seoul Seoul-teukbyeolsi [Seoul] 03722 Korea, Republic of Details
Asan Medical Center Seoul Seoul-teukbyeolsi [Seoul] 05505 Korea, Republic of Details
Samsung Medical Center Seoul Seoul-teukbyeolsi [Seoul] 06351 Korea, Republic of Details
The Catholic University of Korea-Seoul St. Mary's Hospital Seocho-Gu Seoul 06591 Korea, Republic of Details
Inje Univ Busan Paik Hospital Busan 47392 Korea, Republic of Details
Ziekenhuisapotheek HagaZiekenhuis Den Haag 2545 AA Netherlands Details
Bravis Ziekenhuis Roosendaal 4708 AE Netherlands Details
Erasmus Medisch Centrum Rotterdam 3015 AA Netherlands Details
Spaarne Gasthuis TM Hoofddorp 2134 Netherlands Details
Middlemore Clinical Trials Papatoetoe Auckland 2025 New Zealand Details
Christchurch Hospital Christchurch 8011 New Zealand Details
Centrum Onkologii Ziemi Lubelskiej Lublin Lubelskie 20-081 Poland Details
Uniwersyteckie Centrum Kliniczne Gdańsk Pomorskie 80-214 Poland Details
Pratia MCM Krakow Krakow 30-510 Poland Details
Centrum Medyczne Pratia Poznań Skórzewo 60-185 Poland Details
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu Wroclaw 50-367 Poland Details
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii Łódź 93510 Poland Details
IPOFG - Lisboa Lisboa 1099-035 Portugal Details
Champalimaud Foundation Lisboa 1400-038 Portugal Details
Budgetary Healthcare Institution of Omsk Region "Clinical Oncology Dispensary" Omsk Omskaya Oblast' 644013 Russian Federation Details
GUZ of Moscow City Clinical Hospital n.a. S.P. Botkin Moscow 125101 Russian Federation Details
Federal State Budgetary Institution "Russian Scientific and Research Institute of Hematology and Transfusiology of Federal Medico-Biological Agency Saint Petersburg 191024 Russian Federation Details
State Medical University named after I.P. Pavlov Saint-Petersburg 197022 Russian Federation Details
Hospital Universitario Virgen de la Victoria Malaga Andalucia 29010 Spain Details
Hospital Duran I Reynals Hospitalet De Llobregat Barcelona 08908 Spain Details
Complejo Hospitalario Universitario de Santiago A Coruña 15706 Spain Details
Hospital Universitari Vall d'Hebron Barcelona 08035 Spain Details
Hospital Clinic de Barcelona Barcelona 08036 Spain Details
Hospital General Universitario Gregorio Marañon Madrid 28007 Spain Details
Hospital Infanta Leonor Madrid 28031 Spain Details
Hospital Universitario Fundación Jiménez Díaz Madrid 28040 Spain Details
Hospital Universitario 12 de Octubre Madrid 28041 Spain Details
Clinica Universidad de Navarra Pamplona 31008 Spain Details
Hospital Universitario Virgen Macarena Sevilla 41009 Spain Details
Hospital Clinico Universitario de Valencia Valencia 46010 Spain Details
Kantonsspital Luzern Luzern 16 Luzern 6000 Switzerland Details
Ospedale Regionale Bellinzona e Valli Bellinzona CH-6500 Switzerland Details
Tri-Service General Hospital Taipei City Taipei 114 Taiwan Details
Chang Gung Memorial Hospital - Chiayi Chiayi County 61363 Taiwan Details
Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung 80756 Taiwan Details
China Medical University Hospital Taichung 40447 Taiwan Details
National Cheng Kung University Hospital Tainan 704 Taiwan Details
National Taiwan University Hospital Taipei 10002 Taiwan Details
Taipei Veterans General Hospital Taipei 11217 Taiwan Details
Chang Gung Memorial Hospital - Linkou Taoyuan City 333 Taiwan Details
Aberdeen Royal Infirmary Aberdeen Aberdeen City AB25 2ZN United Kingdom Details
Churchill Hospital Headington Oxford OX3 7LE United Kingdom Details
Beatson West of Scotland Cancer Centre Glasgow Stratchclyde G12OYN United Kingdom Details
Royal Marsden Hospital Sutton Surrey SM2 5PT United Kingdom Details
GenesisCare Cambridge Newmarket CB8 7XN United Kingdom Details
City Hospital, Nottingham University Hospitals Nottingham NG5 1PB United Kingdom Details
Derriford Hospital Plymouth Pl6 8DH United Kingdom Details
GenesisCare, Windsor Windsor SL4 3HD United Kingdom Details
New Cross Hospital Wolverhampton WV10 0QP United Kingdom Details
*Shaded cells indicate that there was no data available from for the field