Drug Detail


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Drug Name MCLA-145
Trade Name
Synonyms MCLA145|MCLA 145|anti-PD-L1/4-1BB bispecific antibody
Drug Descriptions

MCLA-145 is a bispecific antibody that binds to CD137 (4-1BB) and PD-L1 and simultaneously activates CD137 and inhibits PD-L1 signaling, which potentially relieves immune suppression resulting in reduced tumor growth (Cancer Res 2019;79(13 Suppl):Abstract nr 539).

DrugClasses Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 89 TNFRSF9 Antibody 16
CAS Registry Number NA
NCIT ID C160772


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Therapy Name Drugs Efficacy Evidence Clinical Trials
MCLA-145 MCLA-145 0 1

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