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|Synonyms||MCLA145|MCLA 145|anti-PD-L1/4-1BB bispecific antibody|
MCLA-145 is a bispecific antibody that binds to CD137 (4-1BB) and PD-L1 and simultaneously activates CD137 and inhibits PD-L1 signaling, which potentially relieves immune suppression resulting in reduced tumor growth (Cancer Res 2019;79(13 Suppl):Abstract nr 539).
|DrugClasses||Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 89 TNFRSF9 Antibody 16|
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|