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Drug Name NG-641
Trade Name
Synonyms NG 641|NG641
Drug Descriptions

NG-641 is an engineered oncolytic enadenotucirev adenovirus expressing a bispecific FAP-TAc T-cell activator that binds to fibroblast activating protein (FAP) on cancer associated fibroblasts and to CD3 on T-lymphocytes, as well as CXCL9, CXCL10, and IFN alpha, which potentially enhances T-cell activation and induces killing of FAP-positive tumor fibroblasts (Cancer Res 2019;79(13 Suppl):Abstract nr 5013).

DrugClasses
CAS Registry Number NA
NCIT ID C168790

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Therapy Name Drugs Efficacy Evidence Clinical Trials
NG-641 NG-641 0 2
NG-641 + Nivolumab NG-641 Nivolumab 0 1
NG-641 + Pembrolizumab NG-641 Pembrolizumab 0 1


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