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Drug Name | COM902 |
Trade Name | |
Synonyms | COM-902|COM 902 |
Drug Descriptions |
COM902 is a monoclonal antibody that targets and binds to the T-cell immunoreceptor with Ig and ITIM domains (TIGIT), inhibiting the interaction between TIGIT and its ligand CD155, leading to increased interaction of the TIGIT-ligands, CD112 and CD155, with the co-stimulatory receptor CD226 and activation of downstream signaling, which may result in an anti-tumor immune response (PMID: 33903974). |
DrugClasses | TIGIT Antibody 19 |
CAS Registry Number | NA |
NCIT ID | C174037 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
COM902 | COM902 | 0 | 1 |