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Drug Name | AGEN1777 |
Trade Name | |
Synonyms | AGEN-1777|AGEN 1777 |
Drug Descriptions |
AGEN1777 is a bispecific antibody that targets both TIGIT and an undisclosed receptor expressed on T-lymphocytes and NK cells, which blocks TIGIT interaction with CD112 and CD155, which results in increased interaction of CD112 and CD155 with the co-stimulatory receptor CD226 and activation of downstream signaling, potentially inducing an anti-tumor immune response (NCI Drug Dictionary). |
DrugClasses | TIGIT Antibody 19 |
CAS Registry Number | NA |
NCIT ID | C183161 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AGEN1777 | AGEN1777 | 0 | 1 |
AGEN1777 + unspecified PD-1 antibody | AGEN1777 unspecified PD-1 antibody | 0 | 1 |