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Drug Name Motesanib Diphosphate
Trade Name
Synonyms AMG 706
Drug Descriptions

Motesanib Diphosphate (AMG 706) is a multi-kinase inhibitor, which inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and inducing tumor regression (PMID: 16951187, PMID: 21422803, PMID: 30816494).

DrugClasses KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27 RET Inhibitor 39 VEGFR Inhibitor (Pan) 32

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Motesanib Diphosphate Carboplatin Motesanib Diphosphate 1 0
Carboplatin + Motesanib Diphosphate + Paclitaxel Carboplatin Motesanib Diphosphate Paclitaxel 1 0
Motesanib Diphosphate Motesanib Diphosphate 6 0
Motesanib Diphosphate + Paclitaxel Motesanib Diphosphate Paclitaxel 1 0


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