Drug Detail


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Drug Name Motesanib Diphosphate
Trade Name
Synonyms AMG 706|AMG706|AMG-706
Drug Descriptions

Motesanib Diphosphate (AMG 706) is a multi-kinase inhibitor, which inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and inducing tumor regression (PMID: 16951187, PMID: 21422803, PMID: 30816494).

DrugClasses KIT Inhibitor 55 PDGFR Inhibitor (Pan) 28 RET Inhibitor 48 VEGFR Inhibitor (Pan) 33
CAS Registry Number 857876-30-3
NCIT ID C48374


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Motesanib Diphosphate Carboplatin Motesanib Diphosphate 0 0
Carboplatin + Motesanib Diphosphate + Paclitaxel Carboplatin Motesanib Diphosphate Paclitaxel 0 0
Motesanib Diphosphate Motesanib Diphosphate 5 0
Motesanib Diphosphate + Paclitaxel Motesanib Diphosphate Paclitaxel 0 0

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