Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Ad5CMV-p53 gene
Trade Name
Synonyms Advexin|INGN-201|RPR/INGN-201|Adeno-p53|Ad-p53
Drug Descriptions

Advexin (Ad5CMV-p53) is a replication-defective adenoviral-CMV vector that encodes a wild-type Tp53 gene, which induces tumor cells to produce wild-type Tp53 to block cell cycle progression (PMID: 19169960).

DrugClasses p53 Gene Therapy 4
CAS Registry Number 600735-73-7


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Ad5CMV-p53 gene Ad5CMV-p53 gene 1 0
Ad5CMV-p53 gene + Capecitabine Ad5CMV-p53 gene Capecitabine 0 1
Ad5CMV-p53 gene + Nivolumab Ad5CMV-p53 gene Nivolumab 0 2
Ad5CMV-p53 gene + Pembrolizumab Ad5CMV-p53 gene Pembrolizumab 0 1
Ad5CMV-p53 gene + unspecified PD-1 antibody Ad5CMV-p53 gene unspecified PD-1 antibody 0 0

Additional content available in CKB BOOST